TY  - JOUR
AU  - Klopstock, Thomas
AU  - Klopstock, Barbara
AU  - Prokisch, Holger
TI  - Mitochondrial replacement approaches: challenges for clinical implementation.
JO  - Genome medicine
VL  - 8
IS  - 1
SN  - 1756-994X
CY  - London
PB  - BioMed Central
M1  - DZNE-2020-05225
SP  - 126
PY  - 2016
AB  - The advent of mitochondrial replacement techniques poses many scientific, regulatory, and ethical questions. Previous studies suggest good safety and efficacy profiles of these techniques, but challenges remain for clinical implementation and international consensus is needed on the regulation of these approaches.
KW  - Animals
KW  - DNA, Mitochondrial: genetics
KW  - Female
KW  - Fertilization in Vitro: ethics
KW  - Genes, Mitochondrial
KW  - Haplorhini
KW  - Humans
KW  - Inheritance Patterns
KW  - Male
KW  - Mice
KW  - Mitochondria: genetics
KW  - Mitochondria: transplantation
KW  - Mitochondrial Diseases: genetics
KW  - Mitochondrial Diseases: pathology
KW  - Mitochondrial Diseases: prevention & control
KW  - Mitochondrial Replacement Therapy: ethics
KW  - Mitochondrial Replacement Therapy: methods
KW  - Oocytes: metabolism
KW  - Oocytes: pathology
KW  - Spermatozoa: cytology
KW  - Spermatozoa: metabolism
KW  - Spindle Apparatus: genetics
KW  - Spindle Apparatus: transplantation
KW  - DNA, Mitochondrial (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:27887638
C2  - pmc:PMC5124262
DO  - DOI:10.1186/s13073-016-0380-2
UR  - https://pub.dzne.de/record/138903
ER  -