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@ARTICLE{Klopstock:138903,
      author       = {Klopstock, Thomas and Klopstock, Barbara and Prokisch,
                      Holger},
      title        = {{M}itochondrial replacement approaches: challenges for
                      clinical implementation.},
      journal      = {Genome medicine},
      volume       = {8},
      number       = {1},
      issn         = {1756-994X},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2020-05225},
      pages        = {126},
      year         = {2016},
      abstract     = {The advent of mitochondrial replacement techniques poses
                      many scientific, regulatory, and ethical questions. Previous
                      studies suggest good safety and efficacy profiles of these
                      techniques, but challenges remain for clinical
                      implementation and international consensus is needed on the
                      regulation of these approaches.},
      subtyp        = {Editorial},
      keywords     = {Animals / DNA, Mitochondrial: genetics / Female /
                      Fertilization in Vitro: ethics / Genes, Mitochondrial /
                      Haplorhini / Humans / Inheritance Patterns / Male / Mice /
                      Mitochondria: genetics / Mitochondria: transplantation /
                      Mitochondrial Diseases: genetics / Mitochondrial Diseases:
                      pathology / Mitochondrial Diseases: prevention $\&$ control
                      / Mitochondrial Replacement Therapy: ethics / Mitochondrial
                      Replacement Therapy: methods / Oocytes: metabolism /
                      Oocytes: pathology / Spermatozoa: cytology / Spermatozoa:
                      metabolism / Spindle Apparatus: genetics / Spindle
                      Apparatus: transplantation / DNA, Mitochondrial (NLM
                      Chemicals)},
      cin          = {AG Levin},
      ddc          = {610},
      cid          = {I:(DE-2719)1111016},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:27887638},
      pmc          = {pmc:PMC5124262},
      doi          = {10.1186/s13073-016-0380-2},
      url          = {https://pub.dzne.de/record/138903},
}