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@ARTICLE{Adams:138904,
author = {Adams, Hieab H H and Hibar, Derrek P and Chouraki, Vincent
and Stein, Jason L and Nyquist, Paul A and Rentería, Miguel
E and Trompet, Stella and Arias-Vasquez, Alejandro and
Seshadri, Sudha and Desrivières, Sylvane and Beecham,
Ashley H and Jahanshad, Neda and Wittfeld, Katharina and Van
der Lee, Sven J and Abramovic, Lucija and Alhusaini, Saud
and Amin, Najaf and Andersson, Micael and Arfanakis,
Konstantinos and Aribisala, Benjamin S and Armstrong, Nicola
J and Athanasiu, Lavinia and Axelsson, Tomas and Beiser,
Alexa and Bernard, Manon and Bis, Joshua C and Blanken,
Laura M E and Blanton, Susan H and Bohlken, Marc M and Boks,
Marco P and Bralten, Janita and Brickman, Adam M and
Carmichael, Owen and Chakravarty, M Mallar and Chauhan,
Ganesh and Chen, Qiang and Ching, Christopher R K and
Cuellar-Partida, Gabriel and Braber, Anouk Den and Doan,
Nhat Trung and Ehrlich, Stefan and Filippi, Irina and Ge,
Tian and Giddaluru, Sudheer and Goldman, Aaron L and
Gottesman, Rebecca F and Greven, Corina U and Grimm, Oliver
and Griswold, Michael E and Guadalupe, Tulio and Hass,
Johanna and Haukvik, Unn K and Hilal, Saima and Hofer, Edith
and Hoehn, David and Holmes, Avram J and Hoogman, Martine
and Janowitz, Deborah and Jia, Tianye and Kasperaviciute,
Dalia and Kim, Sungeun and Klein, Marieke and Kraemer, Bernd
and Lee, Phil H and Liao, Jiemin and Liewald, David C M and
Lopez, Lorna M and Luciano, Michelle and Macare, Christine
and Marquand, Andre and Matarin, Mar and Mather, Karen A and
Mattheisen, Manuel and Mazoyer, Bernard and McKay, David R
and McWhirter, Rebekah and Milaneschi, Yuri and
Mirza-Schreiber, Nazanin and Muetzel, Ryan L and Maniega,
Susana Muñoz and Nho, Kwangsik and Nugent, Allison C and
Loohuis, Loes M Olde and Oosterlaan, Jaap and Papmeyer,
Martina and Pappa, Irene and Pirpamer, Lukas and Pudas, Sara
and Pütz, Benno and Rajan, Kumar B and Ramasamy,
Adaikalavan and Richards, Jennifer S and Risacher, Shannon L
and Roiz-Santiañez, Roberto and Rommelse, Nanda and Rose,
Emma J and Royle, Natalie A and Rundek, Tatjana and Sämann,
Philipp G and Satizabal, Claudia L and Schmaal, Lianne and
Schork, Andrew J and Shen, Li and Shin, Jean and Shumskaya,
Elena and Smith, Albert V and Sprooten, Emma and Strike,
Lachlan T and Teumer, Alexander and Thomson, Russell and
Tordesillas-Gutierrez, Diana and Toro, Roberto and Trabzuni,
Daniah and Vaidya, Dhananjay and Van der Grond, Jeroen and
Van der Meer, Dennis and Van Donkelaar, Marjolein M J and
Van Eijk, Kristel R and Van Erp, Theo G M and Van Rooij,
Daan and Walton, Esther and Westlye, Lars T and Whelan,
Christopher D and Windham, Beverly G and Winkler, Anderson M
and Woldehawariat, Girma and Wolf, Christiane and Wolfers,
Thomas and Xu, Bing and Yanek, Lisa R and Yang, Jingyun and
Zijdenbos, Alex and Zwiers, Marcel P and Agartz, Ingrid and
Aggarwal, Neelum T and Almasy, Laura and Ames, David and
Amouyel, Philippe and Andreassen, Ole A and Arepalli,
Sampath and Assareh, Amelia A and Barral, Sandra and Bastin,
Mark E and Becker, Diane M and Becker, James T and Bennett,
David A and Blangero, John and van Bokhoven, Hans and
Boomsma, Dorret I and Brodaty, Henry and Brouwer, Rachel M
and Brunner, Han G and Buckner, Randy L and Buitelaar, Jan K
and Bulayeva, Kazima B and Cahn, Wiepke and Calhoun, Vince D
and Cannon, Dara M and Cavalleri, Gianpiero L and Chen,
Christopher and Cheng, Ching-Yu and Cichon, Sven and
Cookson, Mark R and Corvin, Aiden and Crespo-Facorro,
Benedicto and Curran, Joanne E and Czisch, Michael and Dale,
Anders M and Davies, Gareth E and De Geus, Eco J C and De
Jager, Philip L and de Zubicaray, Greig I and Delanty,
Norman and Depondt, Chantal and DeStefano, Anita L and
Dillman, Allissa and Djurovic, Srdjan and Donohoe, Gary and
Drevets, Wayne C and Duggirala, Ravi and Dyer, Thomas D and
Erk, Susanne and Espeseth, Thomas and Evans, Denis A and
Fedko, Iryna O and Fernández, Guillén and Ferrucci, Luigi
and Fisher, Simon E and Fleischman, Debra A and Ford, Ian
and Foroud, Tatiana M and Fox, Peter T and Francks, Clyde
and Fukunaga, Masaki and Gibbs, J Raphael and Glahn, David C
and Gollub, Randy L and Göring, Harald H H and Grabe, Hans
J and Green, Robert C and Gruber, Oliver and Gudnason,
Vilmundur and Guelfi, Sebastian and Hansell, Narelle K and
Hardy, John and Hartman, Catharina A and Hashimoto, Ryota
and Hegenscheid, Katrin and Heinz, Andreas and Le Hellard,
Stephanie and Hernandez, Dena G and Heslenfeld, Dirk J and
Ho, Beng-Choon and Hoekstra, Pieter J and Hoffmann, Wolfgang
and Hofman, Albert and Holsboer, Florian and Homuth, Georg
and Hosten, Norbert and Hottenga, Jouke-Jan and Hulshoff
Pol, Hilleke E and Ikeda, Masashi and Ikram, M Kamran and
Jack, Clifford R and Jenkinson, Mark and Johnson, Robert and
Jönsson, Erik G and Jukema, J Wouter and Kahn, René S and
Kanai, Ryota and Kloszewska, Iwona and Knopman, David S and
Kochunov, Peter and Kwok, John B and Lawrie, Stephen M and
Lemaître, Hervé and Liu, Xinmin and Longo, Dan L and
Longstreth, W. T. and Lopez, Oscar L and Lovestone, Simon
and Martinez, Oliver and Martinot, Jean-Luc and Mattay,
Venkata S and McDonald, Colm and McIntosh, Andrew M and
McMahon, Katie L and McMahon, Francis J and Mecocci,
Patrizia and Melle, Ingrid and Meyer-Lindenberg, Andreas and
Mohnke, Sebastian and Montgomery, Grant W and Morris, Derek
W and Mosley, Thomas H and Mühleisen, Thomas W and
Müller-Myhsok, Bertram and Nalls, Michael A and Nauck,
Matthias and Nichols, Thomas E and Niessen, Wiro J and
Nöthen, Markus M and Nyberg, Lars and Ohi, Kazutaka and
Olvera, Rene L and Ophoff, Roel A and Pandolfo, Massimo and
Paus, Tomas and Pausova, Zdenka and Penninx, Brenda W J H
and Pike, G Bruce and Potkin, Steven G and Psaty, Bruce M
and Reppermund, Simone and Rietschel, Marcella and Roffman,
Joshua L and Romanczuk-Seiferth, Nina and Rotter, Jerome I
and Ryten, Mina and Sacco, Ralph L and Sachdev, Perminder S
and Saykin, Andrew J and Schmidt, Reinhold and Schofield,
Peter R and Sigurdsson, Sigurdur and Simmons, Andy and
Singleton, Andrew and Sisodiya, Sanjay M and Smith, Colin
and Smoller, Jordan W and Soininen, Hilkka and Srikanth,
Velandai and Steen, Vidar M and Stott, David J and Sussmann,
Jessika E and Thalamuthu, Anbupalam and Tiemeier, Henning
and Toga, Arthur W and Traynor, Bryan J and Troncoso, Juan
and Turner, Jessica A and Tzourio, Christophe and
Uitterlinden, Andre G and Hernández, Maria C Valdés and
Van der Brug, Marcel and Van der Lugt, Aad and Van der Wee,
Nic J A and Van Duijn, Cornelia M and Van Haren, Neeltje E M
and Van T Ent, Dennis and Van Tol, Marie-Jose and
Vardarajan, Badri N and Veltman, Dick J and Vernooij, Meike
W and Völzke, Henry and Walter, Henrik and Wardlaw, Joanna
M and Wassink, Thomas H and Weale, Michael E and Weinberger,
Daniel R and Weiner, Michael W and Wen, Wei and Westman,
Eric and White, Tonya and Wong, Tien Y and Wright, Clinton B
and Zielke, H Ronald and Zonderman, Alan B and Deary, Ian J
and DeCarli, Charles and Schmidt, Helena and Martin,
Nicholas G and De Craen, Anton J M and Wright, Margaret J
and Launer, Lenore J and Schumann, Gunter and Fornage,
Myriam and Franke, Barbara and Debette, Stéphanie and
Medland, Sarah E and Ikram, M Arfan and Thompson, Paul M},
title = {{N}ovel genetic loci underlying human intracranial volume
identified through genome-wide association.},
journal = {Nature reviews / Neuroscience},
volume = {19},
number = {12},
issn = {1097-6256},
address = {London},
publisher = {Nature Publ. Group58142},
reportid = {DZNE-2020-05226},
pages = {1569-1582},
year = {2016},
abstract = {Intracranial volume reflects the maximally attained brain
size during development, and remains stable with loss of
tissue in late life. It is highly heritable, but the
underlying genes remain largely undetermined. In a
genome-wide association study of 32,438 adults, we
discovered five previously unknown loci for intracranial
volume and confirmed two known signals. Four of the loci
were also associated with adult human stature, but these
remained associated with intracranial volume after adjusting
for height. We found a high genetic correlation with child
head circumference (ρgenetic = 0.748), which indicates a
similar genetic background and allowed us to identify four
additional loci through meta-analysis (Ncombined = 37,345).
Variants for intracranial volume were also related to
childhood and adult cognitive function, and Parkinson's
disease, and were enriched near genes involved in growth
pathways, including PI3K-AKT signaling. These findings
identify the biological underpinnings of intracranial volume
and their link to physiological and pathological traits.},
keywords = {White People / Brain: growth $\&$ development / Brain:
pathology / Cognition: physiology / European Continental
Ancestry Group / Genetic Loci: genetics / Genetic
Predisposition to Disease / Genome-Wide Association Study:
methods / Humans / Oncogene Protein v-akt: genetics /
Parkinson Disease: genetics / Phenotype /
Phosphatidylinositol 3-Kinases: genetics / Polymorphism,
Single Nucleotide: genetics / Phosphatidylinositol 3-Kinases
(NLM Chemicals) / Oncogene Protein v-akt (NLM Chemicals)},
cin = {AG Grabe / AG Heutink 1 / Translational Health Care
Research},
ddc = {570},
cid = {I:(DE-2719)5000001 / I:(DE-2719)1210002 /
I:(DE-2719)1510600},
pnm = {344 - Clinical and Health Care Research (POF3-344) / 345 -
Population Studies and Genetics (POF3-345)},
pid = {G:(DE-HGF)POF3-344 / G:(DE-HGF)POF3-345},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:27694991},
pmc = {pmc:PMC5227112},
doi = {10.1038/nn.4398},
url = {https://pub.dzne.de/record/138904},
}
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