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000138922 0247_ $$2doi$$a10.3233/JAD-160316
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000138922 041__ $$aEnglish
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000138922 1001_ $$0P:(DE-HGF)0$$aDronse, Julian$$b0$$eCorresponding author
000138922 245__ $$aIn vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease.
000138922 260__ $$aAmsterdam$$bIOS Press$$c2017
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000138922 520__ $$aThe clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition of amyloid-β. We assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of Alzheimer's disease using novel multimodal PET imaging techniques. Tau pathology was primarily observed in brain regions related to clinical symptoms and overlapped with areas of hypometabolism. In contrast, amyloid-β deposition was diffusely distributed over the entire cortex. Tau PET imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of Alzheimer's disease.
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000138922 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000138922 650_7 $$2NLM Chemicals$$aCarbolines
000138922 650_7 $$2NLM Chemicals$$atau Proteins
000138922 650_7 $$00Z5B2CJX4D$$2NLM Chemicals$$aFluorodeoxyglucose F18
000138922 650_7 $$0J09QS3Z3WB$$2NLM Chemicals$$a7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole
000138922 650_2 $$2MeSH$$aAlzheimer Disease: complications
000138922 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging
000138922 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000138922 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000138922 650_2 $$2MeSH$$aAtrophy: etiology
000138922 650_2 $$2MeSH$$aBrain: diagnostic imaging
000138922 650_2 $$2MeSH$$aBrain: metabolism
000138922 650_2 $$2MeSH$$aBrain: pathology
000138922 650_2 $$2MeSH$$aCarbolines: metabolism
000138922 650_2 $$2MeSH$$aCognition Disorders: diagnostic imaging
000138922 650_2 $$2MeSH$$aCognition Disorders: etiology
000138922 650_2 $$2MeSH$$aCorticomedial Nuclear Complex: pathology
000138922 650_2 $$2MeSH$$aExecutive Function
000138922 650_2 $$2MeSH$$aFemale
000138922 650_2 $$2MeSH$$aFluorodeoxyglucose F18: metabolism
000138922 650_2 $$2MeSH$$aHumans
000138922 650_2 $$2MeSH$$aLanguage Disorders: etiology
000138922 650_2 $$2MeSH$$aMale
000138922 650_2 $$2MeSH$$aNeuropsychological Tests
000138922 650_2 $$2MeSH$$aPositron-Emission Tomography
000138922 650_2 $$2MeSH$$atau Proteins: metabolism
000138922 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b1$$udzne
000138922 7001_ $$aBischof, Gérard N$$b2
000138922 7001_ $$avon Reutern, Boris$$b3
000138922 7001_ $$0P:(DE-2719)2811327$$aFaber, Jennifer$$b4$$udzne
000138922 7001_ $$aHammes, Jochen$$b5
000138922 7001_ $$aKuhnert, Georg$$b6
000138922 7001_ $$aNeumaier, Bernd$$b7
000138922 7001_ $$aOnur, Oezguer A$$b8
000138922 7001_ $$aKukolja, Juraj$$b9
000138922 7001_ $$0P:(DE-2719)2812285$$aEimeren, Thilo$$b10$$udzne
000138922 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b11$$udzne
000138922 7001_ $$aFink, Gereon R$$b12
000138922 7001_ $$0P:(DE-2719)2810314$$aKlockgether, Thomas$$b13$$udzne
000138922 7001_ $$0P:(DE-2719)2811239$$aDrzezga, Alexander$$b14$$eLast author$$udzne
000138922 77318 $$2Crossref$$3journal-article$$a10.3233/jad-160316$$b : IOS Press, 2016-11-19$$n2$$p465-471$$tJournal of Alzheimer's Disease$$v55$$x1387-2877$$y2016
000138922 773__ $$0PERI:(DE-600)2070772-1$$a10.3233/JAD-160316$$gVol. 55, no. 2, p. 465 - 471$$n2$$p465-471$$q55:2<465 - 471$$tJournal of Alzheimer's disease$$v55$$x1387-2877$$y2017
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