TY  - JOUR
AU  - Dronse, Julian
AU  - Fliessbach, Klaus
AU  - Bischof, Gérard N
AU  - von Reutern, Boris
AU  - Faber, Jennifer
AU  - Hammes, Jochen
AU  - Kuhnert, Georg
AU  - Neumaier, Bernd
AU  - Onur, Oezguer A
AU  - Kukolja, Juraj
AU  - Eimeren, Thilo
AU  - Jessen, Frank
AU  - Fink, Gereon R
AU  - Klockgether, Thomas
AU  - Drzezga, Alexander
TI  - In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease.
JO  - Journal of Alzheimer's disease
VL  - 55
IS  - 2
SN  - 1387-2877
CY  - Amsterdam
PB  - IOS Press
M1  - DZNE-2020-05244
SP  - 465-471
PY  - 2017
AB  - The clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition of amyloid-β. We assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of Alzheimer's disease using novel multimodal PET imaging techniques. Tau pathology was primarily observed in brain regions related to clinical symptoms and overlapped with areas of hypometabolism. In contrast, amyloid-β deposition was diffusely distributed over the entire cortex. Tau PET imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of Alzheimer's disease.
KW  - Alzheimer Disease: complications
KW  - Alzheimer Disease: diagnostic imaging
KW  - Alzheimer Disease: pathology
KW  - Amyloid beta-Peptides: metabolism
KW  - Atrophy: etiology
KW  - Brain: diagnostic imaging
KW  - Brain: metabolism
KW  - Brain: pathology
KW  - Carbolines: metabolism
KW  - Cognition Disorders: diagnostic imaging
KW  - Cognition Disorders: etiology
KW  - Corticomedial Nuclear Complex: pathology
KW  - Executive Function
KW  - Female
KW  - Fluorodeoxyglucose F18: metabolism
KW  - Humans
KW  - Language Disorders: etiology
KW  - Male
KW  - Neuropsychological Tests
KW  - Positron-Emission Tomography
KW  - tau Proteins: metabolism
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - Carbolines (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
KW  - Fluorodeoxyglucose F18 (NLM Chemicals)
KW  - 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:27802224
DO  - DOI:10.3233/JAD-160316
UR  - https://pub.dzne.de/record/138922
ER  -