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| Home > Publications Database > In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease. > print |
| Home > Publications Database > In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease. > print |
| 001 | 138922 | ||
| 005 | 20240321220525.0 | ||
| 024 | 7 | _ | |a 10.3233/JAD-160316 |2 doi |
| 024 | 7 | _ | |a pmid:27802224 |2 pmid |
| 024 | 7 | _ | |a 1387-2877 |2 ISSN |
| 024 | 7 | _ | |a 1875-8908 |2 ISSN |
| 024 | 7 | _ | |a altmetric:13358066 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-05244 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Dronse, Julian |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer's Disease. |
| 260 | _ | _ | |a Amsterdam |c 2017 |b IOS Press |
| 264 | _ | 1 | |3 print |2 Crossref |b IOS Press |c 2016-11-19 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1710940439_2066 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition of amyloid-β. We assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of Alzheimer's disease using novel multimodal PET imaging techniques. Tau pathology was primarily observed in brain regions related to clinical symptoms and overlapped with areas of hypometabolism. In contrast, amyloid-β deposition was diffusely distributed over the entire cortex. Tau PET imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of Alzheimer's disease. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Amyloid beta-Peptides |2 NLM Chemicals |
| 650 | _ | 7 | |a Carbolines |2 NLM Chemicals |
| 650 | _ | 7 | |a tau Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Fluorodeoxyglucose F18 |0 0Z5B2CJX4D |2 NLM Chemicals |
| 650 | _ | 7 | |a 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole |0 J09QS3Z3WB |2 NLM Chemicals |
| 650 | _ | 2 | |a Alzheimer Disease: complications |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: pathology |2 MeSH |
| 650 | _ | 2 | |a Amyloid beta-Peptides: metabolism |2 MeSH |
| 650 | _ | 2 | |a Atrophy: etiology |2 MeSH |
| 650 | _ | 2 | |a Brain: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Brain: metabolism |2 MeSH |
| 650 | _ | 2 | |a Brain: pathology |2 MeSH |
| 650 | _ | 2 | |a Carbolines: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cognition Disorders: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Cognition Disorders: etiology |2 MeSH |
| 650 | _ | 2 | |a Corticomedial Nuclear Complex: pathology |2 MeSH |
| 650 | _ | 2 | |a Executive Function |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Fluorodeoxyglucose F18: metabolism |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Language Disorders: etiology |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Neuropsychological Tests |2 MeSH |
| 650 | _ | 2 | |a Positron-Emission Tomography |2 MeSH |
| 650 | _ | 2 | |a tau Proteins: metabolism |2 MeSH |
| 700 | 1 | _ | |a Fliessbach, Klaus |0 P:(DE-2719)2811326 |b 1 |u dzne |
| 700 | 1 | _ | |a Bischof, Gérard N |b 2 |
| 700 | 1 | _ | |a von Reutern, Boris |b 3 |
| 700 | 1 | _ | |a Faber, Jennifer |0 P:(DE-2719)2811327 |b 4 |u dzne |
| 700 | 1 | _ | |a Hammes, Jochen |b 5 |
| 700 | 1 | _ | |a Kuhnert, Georg |b 6 |
| 700 | 1 | _ | |a Neumaier, Bernd |b 7 |
| 700 | 1 | _ | |a Onur, Oezguer A |b 8 |
| 700 | 1 | _ | |a Kukolja, Juraj |b 9 |
| 700 | 1 | _ | |a Eimeren, Thilo |0 P:(DE-2719)2812285 |b 10 |u dzne |
| 700 | 1 | _ | |a Jessen, Frank |0 P:(DE-2719)2000032 |b 11 |u dzne |
| 700 | 1 | _ | |a Fink, Gereon R |b 12 |
| 700 | 1 | _ | |a Klockgether, Thomas |0 P:(DE-2719)2810314 |b 13 |u dzne |
| 700 | 1 | _ | |a Drzezga, Alexander |0 P:(DE-2719)2811239 |b 14 |e Last author |u dzne |
| 773 | 1 | 8 | |a 10.3233/jad-160316 |b : IOS Press, 2016-11-19 |n 2 |p 465-471 |3 journal-article |2 Crossref |t Journal of Alzheimer's Disease |v 55 |y 2016 |x 1387-2877 |
| 773 | _ | _ | |a 10.3233/JAD-160316 |g Vol. 55, no. 2, p. 465 - 471 |0 PERI:(DE-600)2070772-1 |n 2 |q 55:2<465 - 471 |p 465-471 |t Journal of Alzheimer's disease |v 55 |y 2017 |x 1387-2877 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/138922/files/DZNE-2020-05244_Restricted.pdf |
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| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S1474-4422(11)70156-9 |2 Crossref |o 10.1016/S1474-4422(11)70156-9 |
| 999 | C | 5 | |y 2012 |2 Crossref |o Crutch 2012 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1212/WNL.0b013e31821103e6 |2 Crossref |o 10.1212/WNL.0b013e31821103e6 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1001/archneur.56.10.1233 |2 Crossref |o 10.1001/archneur.56.10.1233 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/brain/awv191 |2 Crossref |o 10.1093/brain/awv191 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/brain/aws327 |2 Crossref |o 10.1093/brain/aws327 |
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| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/brain/awl269 |2 Crossref |o 10.1093/brain/awl269 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/brain/123.3.484 |2 Crossref |o 10.1093/brain/123.3.484 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.3233/JAD-2010-1337 |2 Crossref |o 10.3233/JAD-2010-1337 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0010-9452(08)70683-X |2 Crossref |o 10.1016/S0010-9452(08)70683-X |
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