TY  - JOUR
AU  - Javadi, Amir-Homayoun
AU  - Emo, Beatrix
AU  - Howard, Lorelei R
AU  - Zisch, Fiona E
AU  - Yu, Yichao
AU  - Knight, Rebecca
AU  - Pinelo Silva, Joao
AU  - Spiers, Hugo J
TI  - Hippocampal and prefrontal processing of network topology to simulate the future.
JO  - Nature Communications
VL  - 8
IS  - 1
SN  - 2041-1723
CY  - [London]
PB  - Nature Publishing Group UK
M1  - DZNE-2020-05440
SP  - 14652
PY  - 2017
AB  - Topological networks lie at the heart of our cities and social milieu. However, it remains unclear how and when the brain processes topological structures to guide future behaviour during everyday life. Using fMRI in humans and a simulation of London (UK), here we show that, specifically when new streets are entered during navigation of the city, right posterior hippocampal activity indexes the change in the number of local topological connections available for future travel and right anterior hippocampal activity reflects global properties of the street entered. When forced detours require re-planning of the route to the goal, bilateral inferior lateral prefrontal activity scales with the planning demands of a breadth-first search of future paths. These results help shape models of how hippocampal and prefrontal regions support navigation, planning and future simulation.
KW  - Adult
KW  - Brain: diagnostic imaging
KW  - Brain: physiology
KW  - Female
KW  - Functional Neuroimaging
KW  - Hippocampus: diagnostic imaging
KW  - Hippocampus: physiology
KW  - Humans
KW  - London
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Prefrontal Cortex: diagnostic imaging
KW  - Prefrontal Cortex: physiology
KW  - Spatial Behavior: physiology
KW  - Spatial Navigation: physiology
KW  - Spatial Processing: physiology
KW  - Young Adult
LB  - PUB:(DE-HGF)16
C6  - pmid:28323817
C2  - pmc:PMC5364395
DO  - DOI:10.1038/ncomms14652
UR  - https://pub.dzne.de/record/139118
ER  -