Journal Article

DZNE-2020-05440

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Hippocampal and prefrontal processing of network topology to simulate the future.

Javadi, A.-H. ; Emo, B. ; Howard, L. R.DZNE* ; Zisch, F. E. ; Yu, Y. ; Knight, R. ; Pinelo Silva, J. ; Spiers, H. J. (Corresponding author)

2017
Nature Publishing Group UK [London]

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Please use a persistent id in citations: doi:10.1038/ncomms14652

Abstract: Topological networks lie at the heart of our cities and social milieu. However, it remains unclear how and when the brain processes topological structures to guide future behaviour during everyday life. Using fMRI in humans and a simulation of London (UK), here we show that, specifically when new streets are entered during navigation of the city, right posterior hippocampal activity indexes the change in the number of local topological connections available for future travel and right anterior hippocampal activity reflects global properties of the street entered. When forced detours require re-planning of the route to the goal, bilateral inferior lateral prefrontal activity scales with the planning demands of a breadth-first search of future paths. These results help shape models of how hippocampal and prefrontal regions support navigation, planning and future simulation.

Keyword(s): Adult (MeSH) ; Brain: diagnostic imaging (MeSH) ; Brain: physiology (MeSH) ; Female (MeSH) ; Functional Neuroimaging (MeSH) ; Hippocampus: diagnostic imaging (MeSH) ; Hippocampus: physiology (MeSH) ; Humans (MeSH) ; London (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Prefrontal Cortex: diagnostic imaging (MeSH) ; Prefrontal Cortex: physiology (MeSH) ; Spatial Behavior: physiology (MeSH) ; Spatial Navigation: physiology (MeSH) ; Spatial Processing: physiology (MeSH) ; Young Adult (MeSH)

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Contributing Institute(s):

1. Aging, Cognition and Technology (AG Wolbers)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2017

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Database coverage:
; ; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; IF >= 15 ; JCR ; SCOPUS ; Web of Science Core Collection ; Zoological Record

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