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@ARTICLE{Javadi:139118,
      author       = {Javadi, Amir-Homayoun and Emo, Beatrix and Howard, Lorelei
                      R and Zisch, Fiona E and Yu, Yichao and Knight, Rebecca and
                      Pinelo Silva, Joao and Spiers, Hugo J},
      title        = {{H}ippocampal and prefrontal processing of network topology
                      to simulate the future.},
      journal      = {Nature Communications},
      volume       = {8},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2020-05440},
      pages        = {14652},
      year         = {2017},
      abstract     = {Topological networks lie at the heart of our cities and
                      social milieu. However, it remains unclear how and when the
                      brain processes topological structures to guide future
                      behaviour during everyday life. Using fMRI in humans and a
                      simulation of London (UK), here we show that, specifically
                      when new streets are entered during navigation of the city,
                      right posterior hippocampal activity indexes the change in
                      the number of local topological connections available for
                      future travel and right anterior hippocampal activity
                      reflects global properties of the street entered. When
                      forced detours require re-planning of the route to the goal,
                      bilateral inferior lateral prefrontal activity scales with
                      the planning demands of a breadth-first search of future
                      paths. These results help shape models of how hippocampal
                      and prefrontal regions support navigation, planning and
                      future simulation.},
      keywords     = {Adult / Brain: diagnostic imaging / Brain: physiology /
                      Female / Functional Neuroimaging / Hippocampus: diagnostic
                      imaging / Hippocampus: physiology / Humans / London /
                      Magnetic Resonance Imaging / Male / Prefrontal Cortex:
                      diagnostic imaging / Prefrontal Cortex: physiology / Spatial
                      Behavior: physiology / Spatial Navigation: physiology /
                      Spatial Processing: physiology / Young Adult},
      cin          = {AG Wolbers},
      ddc          = {500},
      cid          = {I:(DE-2719)1310002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28323817},
      pmc          = {pmc:PMC5364395},
      doi          = {10.1038/ncomms14652},
      url          = {https://pub.dzne.de/record/139118},
}