%0 Journal Article
%A Franzmeier, Nicolai
%A Duering, Marco
%A Weiner, Michael
%A Dichgans, Martin
%A Ewers, Michael
%A Initiative, Alzheimer's Disease Neuroimaging
%T Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease.
%J Neurology
%V 88
%N 11
%@ 0028-3878
%C [S.l.]
%I Ovid
%M DZNE-2020-05470
%P 1054-1061
%D 2017
%X To test whether higher global functional connectivity of the left frontal cortex (LFC) in Alzheimer disease (AD) is associated with more years of education (a proxy of cognitive reserve [CR]) and mitigates the association between AD-related fluorodeoxyglucose (FDG)-PET hypometabolism and episodic memory.Forty-four amyloid-PET-positive patients with amnestic mild cognitive impairment (MCI-Aβ+) and 24 amyloid-PET-negative healthy controls (HC) were included. Voxel-based linear regression analyses were used to test the association between years of education and FDG-PET in MCI-Aβ+, controlled for episodic memory performance. Global LFC (gLFC) connectivity was computed through seed-based resting-state fMRI correlations between the LFC (seed) and each voxel in the gray matter. In linear regression analyses, education as a predictor of gLFC connectivity and the interaction of gLFC connectivity × FDG-PET hypometabolism on episodic memory were tested.FDG-PET metabolism in the precuneus was reduced in MCI-Aβ+ compared to HC (p = 0.028), with stronger reductions observed in MCI-Aβ+ with more years of education (p = 0.006). In MCI-Aβ+, higher gLFC connectivity was associated with more years of education (p = 0.021). At higher levels of gLFC connectivity, the association between precuneus FDG-PET hypometabolism and lower memory performance was attenuated (p = 0.027).Higher gLFC connectivity is a functional substrate of CR that helps to maintain episodic memory relatively well in the face of emerging FDG-PET hypometabolism in early-stage AD.
%K Alzheimer Disease: complications
%K Alzheimer Disease: diagnostic imaging
%K Alzheimer Disease: pathology
%K Chi-Square Distribution
%K Cognition Disorders: etiology
%K Cognitive Reserve: physiology
%K Epilepsy: diagnostic imaging
%K Epilepsy: etiology
%K Female
%K Fluorodeoxyglucose F18: metabolism
%K Frontal Lobe: diagnostic imaging
%K Frontal Lobe: pathology
%K Functional Laterality: physiology
%K Humans
%K Magnetic Resonance Imaging
%K Male
%K Nerve Net: pathology
%K Neuropsychological Tests
%K Oxygen: blood
%K Positron-Emission Tomography
%K Prodromal Symptoms
%K Fluorodeoxyglucose F18 (NLM Chemicals)
%K Oxygen (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28188306
%2 pmc:PMC5384837
%R 10.1212/WNL.0000000000003711
%U https://pub.dzne.de/record/139148