TY  - JOUR
AU  - Franzmeier, Nicolai
AU  - Duering, Marco
AU  - Weiner, Michael
AU  - Dichgans, Martin
AU  - Ewers, Michael
AU  - Initiative, Alzheimer's Disease Neuroimaging
TI  - Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease.
JO  - Neurology
VL  - 88
IS  - 11
SN  - 0028-3878
CY  - [S.l.]
PB  - Ovid
M1  - DZNE-2020-05470
SP  - 1054-1061
PY  - 2017
AB  - To test whether higher global functional connectivity of the left frontal cortex (LFC) in Alzheimer disease (AD) is associated with more years of education (a proxy of cognitive reserve [CR]) and mitigates the association between AD-related fluorodeoxyglucose (FDG)-PET hypometabolism and episodic memory.Forty-four amyloid-PET-positive patients with amnestic mild cognitive impairment (MCI-Aβ+) and 24 amyloid-PET-negative healthy controls (HC) were included. Voxel-based linear regression analyses were used to test the association between years of education and FDG-PET in MCI-Aβ+, controlled for episodic memory performance. Global LFC (gLFC) connectivity was computed through seed-based resting-state fMRI correlations between the LFC (seed) and each voxel in the gray matter. In linear regression analyses, education as a predictor of gLFC connectivity and the interaction of gLFC connectivity × FDG-PET hypometabolism on episodic memory were tested.FDG-PET metabolism in the precuneus was reduced in MCI-Aβ+ compared to HC (p = 0.028), with stronger reductions observed in MCI-Aβ+ with more years of education (p = 0.006). In MCI-Aβ+, higher gLFC connectivity was associated with more years of education (p = 0.021). At higher levels of gLFC connectivity, the association between precuneus FDG-PET hypometabolism and lower memory performance was attenuated (p = 0.027).Higher gLFC connectivity is a functional substrate of CR that helps to maintain episodic memory relatively well in the face of emerging FDG-PET hypometabolism in early-stage AD.
KW  - Alzheimer Disease: complications
KW  - Alzheimer Disease: diagnostic imaging
KW  - Alzheimer Disease: pathology
KW  - Chi-Square Distribution
KW  - Cognition Disorders: etiology
KW  - Cognitive Reserve: physiology
KW  - Epilepsy: diagnostic imaging
KW  - Epilepsy: etiology
KW  - Female
KW  - Fluorodeoxyglucose F18: metabolism
KW  - Frontal Lobe: diagnostic imaging
KW  - Frontal Lobe: pathology
KW  - Functional Laterality: physiology
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Nerve Net: pathology
KW  - Neuropsychological Tests
KW  - Oxygen: blood
KW  - Positron-Emission Tomography
KW  - Prodromal Symptoms
KW  - Fluorodeoxyglucose F18 (NLM Chemicals)
KW  - Oxygen (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:28188306
C2  - pmc:PMC5384837
DO  - DOI:10.1212/WNL.0000000000003711
UR  - https://pub.dzne.de/record/139148
ER  -