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@ARTICLE{Franzmeier:139148,
      author       = {Franzmeier, Nicolai and Duering, Marco and Weiner, Michael
                      and Dichgans, Martin and Ewers, Michael and Initiative,
                      Alzheimer's Disease Neuroimaging},
      title        = {{L}eft frontal cortex connectivity underlies cognitive
                      reserve in prodromal {A}lzheimer disease.},
      journal      = {Neurology},
      volume       = {88},
      number       = {11},
      issn         = {0028-3878},
      address      = {[S.l.]},
      publisher    = {Ovid},
      reportid     = {DZNE-2020-05470},
      pages        = {1054-1061},
      year         = {2017},
      abstract     = {To test whether higher global functional connectivity of
                      the left frontal cortex (LFC) in Alzheimer disease (AD) is
                      associated with more years of education (a proxy of
                      cognitive reserve [CR]) and mitigates the association
                      between AD-related fluorodeoxyglucose (FDG)-PET
                      hypometabolism and episodic memory.Forty-four
                      amyloid-PET-positive patients with amnestic mild cognitive
                      impairment (MCI-Aβ+) and 24 amyloid-PET-negative healthy
                      controls (HC) were included. Voxel-based linear regression
                      analyses were used to test the association between years of
                      education and FDG-PET in MCI-Aβ+, controlled for episodic
                      memory performance. Global LFC (gLFC) connectivity was
                      computed through seed-based resting-state fMRI correlations
                      between the LFC (seed) and each voxel in the gray matter. In
                      linear regression analyses, education as a predictor of gLFC
                      connectivity and the interaction of gLFC connectivity ×
                      FDG-PET hypometabolism on episodic memory were
                      tested.FDG-PET metabolism in the precuneus was reduced in
                      MCI-Aβ+ compared to HC (p = 0.028), with stronger
                      reductions observed in MCI-Aβ+ with more years of education
                      (p = 0.006). In MCI-Aβ+, higher gLFC connectivity was
                      associated with more years of education (p = 0.021). At
                      higher levels of gLFC connectivity, the association between
                      precuneus FDG-PET hypometabolism and lower memory
                      performance was attenuated (p = 0.027).Higher gLFC
                      connectivity is a functional substrate of CR that helps to
                      maintain episodic memory relatively well in the face of
                      emerging FDG-PET hypometabolism in early-stage AD.},
      keywords     = {Alzheimer Disease: complications / Alzheimer Disease:
                      diagnostic imaging / Alzheimer Disease: pathology /
                      Chi-Square Distribution / Cognition Disorders: etiology /
                      Cognitive Reserve: physiology / Epilepsy: diagnostic imaging
                      / Epilepsy: etiology / Female / Fluorodeoxyglucose F18:
                      metabolism / Frontal Lobe: diagnostic imaging / Frontal
                      Lobe: pathology / Functional Laterality: physiology / Humans
                      / Magnetic Resonance Imaging / Male / Nerve Net: pathology /
                      Neuropsychological Tests / Oxygen: blood / Positron-Emission
                      Tomography / Prodromal Symptoms / Fluorodeoxyglucose F18
                      (NLM Chemicals) / Oxygen (NLM Chemicals)},
      cin          = {Clinical Dementia Research München},
      ddc          = {610},
      cid          = {I:(DE-2719)1111016},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28188306},
      pmc          = {pmc:PMC5384837},
      doi          = {10.1212/WNL.0000000000003711},
      url          = {https://pub.dzne.de/record/139148},
}