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000139329 0247_ $$2doi$$a10.1016/bs.apcsb.2016.09.001
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000139329 0247_ $$2ISSN$$a1876-1623
000139329 0247_ $$2ISSN$$a1876-1631
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000139329 037__ $$aDZNE-2020-05651
000139329 041__ $$aEnglish
000139329 082__ $$a540
000139329 1001_ $$0P:(DE-2719)2811660$$aSchultze, Joachim$$b0$$eFirst author$$udzne
000139329 245__ $$aChromatin Remodeling in Monocyte and Macrophage Activation.
000139329 260__ $$aHeidelberg$$bElsevier$$c2017
000139329 264_1 $$2Crossref$$3print$$bElsevier$$c2017-01-01
000139329 29510 $$aChromatin Remodelling and Immunity / Schultze, J.L.  ;  : Elsevier, 2017,  ; ISSN: 18761623 ; ISBN: 9780128123928 ; doi:10.1016/bs.apcsb.2016.09.001
000139329 300__ $$a1 - 15
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000139329 4900_ $$aAdvances in Protein Chemistry and Structural Biology$$v106
000139329 520__ $$aIncreasing evidence collected during the last years supports the idea that monocyte and macrophage activation is not only associated with transcriptional changes but also changes in the chromatin landscape. Moreover, the introduction of a multidimensional model of macrophage activation allows a more precise description of monocytes and macrophages under homeostatic and pathophysiological conditions. Monocytes and macrophages are masters of integrating microenvironmental signals, thereby reshaping their chromatin landscape and as a consequence their transcriptional and functional programs. Albeit these cells share a large number of epigenetic landmarks, their chromatin is significantly shaped by environmental signals. The chromatin landscape of any given tissue macrophage is a rather specific fingerprint of these cells, which is directly linked to tissue-specific functions of these cells. Moreover, chromatin remodeling in response to stress signals also seems to be an important mechanism of these cells to increase their readiness for future stressors. Understanding this sophisticated epigenetic regulatory network in monocytes and macrophages will open up new avenues toward tissue- and disease-specific therapeutic strategies in many of the chronic inflammatory diseases our societies are currently facing.
000139329 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000139329 650_2 $$2MeSH$$aChromatin Assembly and Disassembly
000139329 650_2 $$2MeSH$$aHumans
000139329 650_2 $$2MeSH$$aImmune Tolerance
000139329 650_2 $$2MeSH$$aLymphocyte Activation
000139329 650_2 $$2MeSH$$aMacrophages: immunology
000139329 650_2 $$2MeSH$$aMonocytes: immunology
000139329 77318 $$2Crossref$$3book-chapter$$a10.1016/bs.apcsb.2016.09.001$$b : Elsevier, 2017-01-01$$p1-15$$tAdvances in Protein Chemistry and Structural Biology$$x1876-1623$$y2017
000139329 773__ $$0PERI:(DE-600)2528495-2$$a10.1016/bs.apcsb.2016.09.001$$p1-15$$tAdvances in protein chemistry and structural biology$$v106$$x1876-1623$$y2017
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000139329 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811660$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
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000139329 9141_ $$y2017
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000139329 9201_ $$0I:(DE-2719)1013038$$kAG Schultze$$lClinical Single Cell Omics (CSCO) / Systems Medicine$$x0
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