Chromatin Remodeling in Monocyte and Macrophage Activation.

Schultze, Joachim

doi:10.1016/bs.apcsb.2016.09.001

Book/Journal Article (Review Article)

DZNE-2020-05651

Chromatin Remodeling in Monocyte and Macrophage Activation.

Schultze, J. (First author)DZNE*

2017
Elsevier Heidelberg

Chromatin Remodelling and Immunity / Schultze, J.L. ; : Elsevier, 2017, ; ISSN: 18761623 ; ISBN: 9780128123928 ; doi:10.1016/bs.apcsb.2016.09.001 Advances in protein chemistry and structural biology 106, 1-15 (2017) [10.1016/bs.apcsb.2016.09.001]

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Abstract: Increasing evidence collected during the last years supports the idea that monocyte and macrophage activation is not only associated with transcriptional changes but also changes in the chromatin landscape. Moreover, the introduction of a multidimensional model of macrophage activation allows a more precise description of monocytes and macrophages under homeostatic and pathophysiological conditions. Monocytes and macrophages are masters of integrating microenvironmental signals, thereby reshaping their chromatin landscape and as a consequence their transcriptional and functional programs. Albeit these cells share a large number of epigenetic landmarks, their chromatin is significantly shaped by environmental signals. The chromatin landscape of any given tissue macrophage is a rather specific fingerprint of these cells, which is directly linked to tissue-specific functions of these cells. Moreover, chromatin remodeling in response to stress signals also seems to be an important mechanism of these cells to increase their readiness for future stressors. Understanding this sophisticated epigenetic regulatory network in monocytes and macrophages will open up new avenues toward tissue- and disease-specific therapeutic strategies in many of the chronic inflammatory diseases our societies are currently facing.

Keyword(s): Chromatin Assembly and Disassembly (MeSH) ; Humans (MeSH) ; Immune Tolerance (MeSH) ; Lymphocyte Activation (MeSH) ; Macrophages: immunology (MeSH) ; Monocytes: immunology (MeSH)