TY  - JOUR
AU  - Schultze, Joachim
TI  - Chromatin Remodeling in Monocyte and Macrophage Activation.
JO  - Advances in protein chemistry and structural biology
VL  - 106
SN  - 1876-1623
CY  - Heidelberg
PB  - Elsevier
M1  - DZNE-2020-05651
T2  - Advances in Protein Chemistry and Structural Biology
SP  - 1-15
PY  - 2017
AB  - Increasing evidence collected during the last years supports the idea that monocyte and macrophage activation is not only associated with transcriptional changes but also changes in the chromatin landscape. Moreover, the introduction of a multidimensional model of macrophage activation allows a more precise description of monocytes and macrophages under homeostatic and pathophysiological conditions. Monocytes and macrophages are masters of integrating microenvironmental signals, thereby reshaping their chromatin landscape and as a consequence their transcriptional and functional programs. Albeit these cells share a large number of epigenetic landmarks, their chromatin is significantly shaped by environmental signals. The chromatin landscape of any given tissue macrophage is a rather specific fingerprint of these cells, which is directly linked to tissue-specific functions of these cells. Moreover, chromatin remodeling in response to stress signals also seems to be an important mechanism of these cells to increase their readiness for future stressors. Understanding this sophisticated epigenetic regulatory network in monocytes and macrophages will open up new avenues toward tissue- and disease-specific therapeutic strategies in many of the chronic inflammatory diseases our societies are currently facing.
KW  - Chromatin Assembly and Disassembly
KW  - Humans
KW  - Immune Tolerance
KW  - Lymphocyte Activation
KW  - Macrophages: immunology
KW  - Monocytes: immunology
LB  - PUB:(DE-HGF)3 ; PUB:(DE-HGF)16
C6  - pmid:28057208
DO  - DOI:10.1016/bs.apcsb.2016.09.001
UR  - https://pub.dzne.de/record/139329
ER  -