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@ARTICLE{Schultze:139329,
      author       = {Schultze, Joachim},
      title        = {{C}hromatin {R}emodeling in {M}onocyte and {M}acrophage
                      {A}ctivation.},
      journal      = {Advances in protein chemistry and structural biology},
      volume       = {106},
      issn         = {1876-1623},
      address      = {Heidelberg},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-05651},
      series       = {Advances in Protein Chemistry and Structural Biology},
      pages        = {1-15},
      year         = {2017},
      comment      = {Chromatin Remodelling and Immunity / Schultze, J.L. ; :
                      Elsevier, 2017, ; ISSN: 18761623 ; ISBN: 9780128123928 ;
                      doi:10.1016/bs.apcsb.2016.09.001},
      booktitle     = {Chromatin Remodelling and Immunity /
                       Schultze, J.L. ; : Elsevier, 2017, ;
                       ISSN: 18761623 ; ISBN: 9780128123928 ;
                       doi:10.1016/bs.apcsb.2016.09.001},
      abstract     = {Increasing evidence collected during the last years
                      supports the idea that monocyte and macrophage activation is
                      not only associated with transcriptional changes but also
                      changes in the chromatin landscape. Moreover, the
                      introduction of a multidimensional model of macrophage
                      activation allows a more precise description of monocytes
                      and macrophages under homeostatic and pathophysiological
                      conditions. Monocytes and macrophages are masters of
                      integrating microenvironmental signals, thereby reshaping
                      their chromatin landscape and as a consequence their
                      transcriptional and functional programs. Albeit these cells
                      share a large number of epigenetic landmarks, their
                      chromatin is significantly shaped by environmental signals.
                      The chromatin landscape of any given tissue macrophage is a
                      rather specific fingerprint of these cells, which is
                      directly linked to tissue-specific functions of these cells.
                      Moreover, chromatin remodeling in response to stress signals
                      also seems to be an important mechanism of these cells to
                      increase their readiness for future stressors. Understanding
                      this sophisticated epigenetic regulatory network in
                      monocytes and macrophages will open up new avenues toward
                      tissue- and disease-specific therapeutic strategies in many
                      of the chronic inflammatory diseases our societies are
                      currently facing.},
      subtyp        = {Review Article},
      keywords     = {Chromatin Assembly and Disassembly / Humans / Immune
                      Tolerance / Lymphocyte Activation / Macrophages: immunology
                      / Monocytes: immunology},
      cin          = {AG Schultze / PRECISE},
      ddc          = {540},
      cid          = {I:(DE-2719)1013038 / I:(DE-2719)1013031},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)3 / PUB:(DE-HGF)16},
      pubmed       = {pmid:28057208},
      doi          = {10.1016/bs.apcsb.2016.09.001},
      url          = {https://pub.dzne.de/record/139329},
}