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| 001 | 139329 | ||
| 005 | 20250318153831.0 | ||
| 024 | 7 | _ | |a 10.1016/bs.apcsb.2016.09.001 |2 doi |
| 024 | 7 | _ | |a pmid:28057208 |2 pmid |
| 024 | 7 | _ | |a 1876-1623 |2 ISSN |
| 024 | 7 | _ | |a 1876-1631 |2 ISSN |
| 024 | 7 | _ | |a altmetric:15533444 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-05651 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 540 |
| 100 | 1 | _ | |a Schultze, Joachim |0 P:(DE-2719)2811660 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Chromatin Remodeling in Monocyte and Macrophage Activation. |
| 260 | _ | _ | |a Heidelberg |c 2017 |b Elsevier |
| 264 | _ | 1 | |3 print |2 Crossref |b Elsevier |c 2017-01-01 |
| 295 | 1 | 0 | |a Chromatin Remodelling and Immunity / Schultze, J.L. ; : Elsevier, 2017, ; ISSN: 18761623 ; ISBN: 9780128123928 ; doi:10.1016/bs.apcsb.2016.09.001 |
| 300 | _ | _ | |a 1 - 15 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Book |0 PUB:(DE-HGF)3 |2 PUB:(DE-HGF) |m book |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1742308643_22055 |2 PUB:(DE-HGF) |x Review Article |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 490 | 0 | _ | |a Advances in Protein Chemistry and Structural Biology |v 106 |
| 520 | _ | _ | |a Increasing evidence collected during the last years supports the idea that monocyte and macrophage activation is not only associated with transcriptional changes but also changes in the chromatin landscape. Moreover, the introduction of a multidimensional model of macrophage activation allows a more precise description of monocytes and macrophages under homeostatic and pathophysiological conditions. Monocytes and macrophages are masters of integrating microenvironmental signals, thereby reshaping their chromatin landscape and as a consequence their transcriptional and functional programs. Albeit these cells share a large number of epigenetic landmarks, their chromatin is significantly shaped by environmental signals. The chromatin landscape of any given tissue macrophage is a rather specific fingerprint of these cells, which is directly linked to tissue-specific functions of these cells. Moreover, chromatin remodeling in response to stress signals also seems to be an important mechanism of these cells to increase their readiness for future stressors. Understanding this sophisticated epigenetic regulatory network in monocytes and macrophages will open up new avenues toward tissue- and disease-specific therapeutic strategies in many of the chronic inflammatory diseases our societies are currently facing. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2017-01-01 |2 Crossref |u https://www.elsevier.com/tdm/userlicense/1.0/ |
| 588 | _ | _ | |a Dataset connected to CrossRef Book Series, PubMed, |
| 650 | _ | 2 | |a Chromatin Assembly and Disassembly |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Immune Tolerance |2 MeSH |
| 650 | _ | 2 | |a Lymphocyte Activation |2 MeSH |
| 650 | _ | 2 | |a Macrophages: immunology |2 MeSH |
| 650 | _ | 2 | |a Monocytes: immunology |2 MeSH |
| 773 | 1 | 8 | |a 10.1016/bs.apcsb.2016.09.001 |b : Elsevier, 2017-01-01 |p 1-15 |3 book-chapter |2 Crossref |t Advances in Protein Chemistry and Structural Biology |y 2017 |x 1876-1623 |
| 773 | _ | _ | |a 10.1016/bs.apcsb.2016.09.001 |0 PERI:(DE-600)2528495-2 |p 1-15 |t Advances in protein chemistry and structural biology |v 106 |y 2017 |x 1876-1623 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/139329/files/DZNE-2020-05651_Restricted.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/139329/files/DZNE-2020-05651_Restricted.pdf?subformat=pdfa |x pdfa |
| 909 | C | O | |p VDB |o oai:pub.dzne.de:139329 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2811660 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Disease Mechanisms and Model Systems |x 0 |
| 914 | 1 | _ | |y 2017 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-11 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-11 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b ADV PROTEIN CHEM STR : 2021 |d 2022-11-11 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b ADV PROTEIN CHEM STR : 2021 |d 2022-11-11 |
| 920 | 1 | _ | |0 I:(DE-2719)1013038 |k AG Schultze |l Clinical Single Cell Omics (CSCO) / Systems Medicine |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1013031 |k PRECISE |l Platform for Single Cell Genomics and Epigenomics |x 1 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a book |
| 980 | _ | _ | |a I:(DE-2719)1013038 |
| 980 | _ | _ | |a I:(DE-2719)1013031 |
| 980 | _ | _ | |a UNRESTRICTED |
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