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000139339 0247_ $$2doi$$a10.1038/nature22795
000139339 0247_ $$2pmid$$apmid:28614294
000139339 0247_ $$2pmc$$apmc:PMC6588541
000139339 0247_ $$2ISSN$$a0028-0836
000139339 0247_ $$2ISSN$$a1476-4687
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000139339 037__ $$aDZNE-2020-05661
000139339 041__ $$aEnglish
000139339 082__ $$a500
000139339 1001_ $$aMcGovern, Naomi$$b0
000139339 245__ $$aHuman fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.
000139339 260__ $$aLondon [u.a.]$$bNature Publ. Group65848$$c2017
000139339 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2017-06-14
000139339 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2017-06-01
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000139339 520__ $$aDuring gestation the developing human fetus is exposed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens from maternal cells, substances from ingested amniotic fluid, food antigens, and microbes. Yet the capacity of the fetal immune system, including antigen-presenting cells, to detect and respond to such stimuli remains unclear. In particular, dendritic cells, which are crucial for effective immunity and tolerance, remain poorly characterized in the developing fetus. Here we show that subsets of antigen-presenting cells can be identified in fetal tissues and are related to adult populations of antigen-presenting cells. Similar to adult dendritic cells, fetal dendritic cells migrate to lymph nodes and respond to toll-like receptor ligation; however, they differ markedly in their response to allogeneic antigens, strongly promoting regulatory T-cell induction and inhibiting T-cell tumour-necrosis factor-α production through arginase-2 activity. Our results reveal a previously unappreciated role of dendritic cells within the developing fetus and indicate that they mediate homeostatic immune-suppressive responses during gestation.
000139339 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000139339 542__ $$2Crossref$$i2017-06-01$$uhttp://www.springer.com/tdm
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000139339 650_7 $$2NLM Chemicals$$aCytokines
000139339 650_7 $$2NLM Chemicals$$aToll-Like Receptors
000139339 650_7 $$0EC 3.5.3.1$$2NLM Chemicals$$aArginase
000139339 650_7 $$0EC 3.5.3.1$$2NLM Chemicals$$aarginase II, human
000139339 650_2 $$2MeSH$$aAdult
000139339 650_2 $$2MeSH$$aArginase: metabolism
000139339 650_2 $$2MeSH$$aCell Movement
000139339 650_2 $$2MeSH$$aCell Proliferation
000139339 650_2 $$2MeSH$$aCytokines: biosynthesis
000139339 650_2 $$2MeSH$$aCytokines: immunology
000139339 650_2 $$2MeSH$$aDendritic Cells: enzymology
000139339 650_2 $$2MeSH$$aDendritic Cells: immunology
000139339 650_2 $$2MeSH$$aFetus: cytology
000139339 650_2 $$2MeSH$$aFetus: enzymology
000139339 650_2 $$2MeSH$$aFetus: immunology
000139339 650_2 $$2MeSH$$aHumans
000139339 650_2 $$2MeSH$$aImmune Tolerance
000139339 650_2 $$2MeSH$$aLymph Nodes: cytology
000139339 650_2 $$2MeSH$$aLymph Nodes: immunology
000139339 650_2 $$2MeSH$$aT-Lymphocytes: cytology
000139339 650_2 $$2MeSH$$aT-Lymphocytes: immunology
000139339 650_2 $$2MeSH$$aT-Lymphocytes, Regulatory: cytology
000139339 650_2 $$2MeSH$$aT-Lymphocytes, Regulatory: immunology
000139339 650_2 $$2MeSH$$aToll-Like Receptors: immunology
000139339 7001_ $$aShin, Amanda$$b1
000139339 7001_ $$aLow, Gillian$$b2
000139339 7001_ $$aLow, Donovan$$b3
000139339 7001_ $$aDuan, Kaibo$$b4
000139339 7001_ $$aYao, Leong Jing$$b5
000139339 7001_ $$aMsallam, Rasha$$b6
000139339 7001_ $$aLow, Ivy$$b7
000139339 7001_ $$aShadan, Nurhidaya Binte$$b8
000139339 7001_ $$aSumatoh, Hermi R$$b9
000139339 7001_ $$aSoon, Erin$$b10
000139339 7001_ $$aLum, Josephine$$b11
000139339 7001_ $$aMok, Esther$$b12
000139339 7001_ $$aHubert, Sandra$$b13
000139339 7001_ $$aSee, Peter$$b14
000139339 7001_ $$aKunxiang, Edwin Huang$$b15
000139339 7001_ $$aLee, Yie Hou$$b16
000139339 7001_ $$aJanela, Baptiste$$b17
000139339 7001_ $$aChoolani, Mahesh$$b18
000139339 7001_ $$aMattar, Citra Nurfarah Zaini$$b19
000139339 7001_ $$aFan, Yiping$$b20
000139339 7001_ $$aLim, Tony Kiat Hon$$b21
000139339 7001_ $$aChan, Dedrick Kok Hong$$b22
000139339 7001_ $$aTan, Ker-Kan$$b23
000139339 7001_ $$aTam, John Kit Chung$$b24
000139339 7001_ $$aSchuster, Christopher$$b25
000139339 7001_ $$aElbe-Bürger, Adelheid$$b26
000139339 7001_ $$aWang, Xiao-Nong$$b27
000139339 7001_ $$aBigley, Venetia$$b28
000139339 7001_ $$aCollin, Matthew$$b29
000139339 7001_ $$aHaniffa, Muzlifah$$b30
000139339 7001_ $$0P:(DE-2719)2813805$$aSchlitzer, Andreas$$b31$$udzne
000139339 7001_ $$aPoidinger, Michael$$b32
000139339 7001_ $$aAlbani, Salvatore$$b33
000139339 7001_ $$aLarbi, Anis$$b34
000139339 7001_ $$aNewell, Evan W$$b35
000139339 7001_ $$aChan, Jerry Kok Yen$$b36
000139339 7001_ $$0P:(DE-HGF)0$$aGinhoux, Florent$$b37$$eCorresponding author
000139339 77318 $$2Crossref$$3journal-article$$a10.1038/nature22795$$b : Springer Science and Business Media LLC, 2017-06-01$$n7660$$p662-666$$tNature$$v546$$x0028-0836$$y2017
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000139339 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588541
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000139339 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2813805$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b31$$kDZNE
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