Journal Article

DZNE-2020-05661

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.

McGovern, N. ; Shin, A. ; Low, G. ; Low, D. ; Duan, K. ; Yao, L. J. ; Msallam, R. ; Low, I. ; Shadan, N. B. ; Sumatoh, H. R. ; Soon, E. ; Lum, J. ; Mok, E. ; Hubert, S. ; See, P. ; Kunxiang, E. H. ; Lee, Y. H. ; Janela, B. ; Choolani, M. ; Mattar, C. N. Z. ; Fan, Y. ; Lim, T. K. H. ; Chan, D. K. H. ; Tan, K.-K. ; Tam, J. K. C. ; Schuster, C. ; Elbe-Bürger, A. ; Wang, X.-N. ; Bigley, V. ; Collin, M. ; Haniffa, M. ; Schlitzer, A.DZNE* ; Poidinger, M. ; Albani, S. ; Larbi, A. ; Newell, E. W. ; Chan, J. K. Y. ; Ginhoux, F. (Corresponding author)

2017
Nature Publ. Group65848 London [u.a.]

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Please use a persistent id in citations: doi:10.1038/nature22795

Abstract: During gestation the developing human fetus is exposed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens from maternal cells, substances from ingested amniotic fluid, food antigens, and microbes. Yet the capacity of the fetal immune system, including antigen-presenting cells, to detect and respond to such stimuli remains unclear. In particular, dendritic cells, which are crucial for effective immunity and tolerance, remain poorly characterized in the developing fetus. Here we show that subsets of antigen-presenting cells can be identified in fetal tissues and are related to adult populations of antigen-presenting cells. Similar to adult dendritic cells, fetal dendritic cells migrate to lymph nodes and respond to toll-like receptor ligation; however, they differ markedly in their response to allogeneic antigens, strongly promoting regulatory T-cell induction and inhibiting T-cell tumour-necrosis factor-α production through arginase-2 activity. Our results reveal a previously unappreciated role of dendritic cells within the developing fetus and indicate that they mediate homeostatic immune-suppressive responses during gestation.

Keyword(s): Adult (MeSH) ; Arginase: metabolism (MeSH) ; Cell Movement (MeSH) ; Cell Proliferation (MeSH) ; Cytokines: biosynthesis (MeSH) ; Cytokines: immunology (MeSH) ; Dendritic Cells: enzymology (MeSH) ; Dendritic Cells: immunology (MeSH) ; Fetus: cytology (MeSH) ; Fetus: enzymology (MeSH) ; Fetus: immunology (MeSH) ; Humans (MeSH) ; Immune Tolerance (MeSH) ; Lymph Nodes: cytology (MeSH) ; Lymph Nodes: immunology (MeSH) ; T-Lymphocytes: cytology (MeSH) ; T-Lymphocytes: immunology (MeSH) ; T-Lymphocytes, Regulatory: cytology (MeSH) ; T-Lymphocytes, Regulatory: immunology (MeSH) ; Toll-Like Receptors: immunology (MeSH) ; Cytokines ; Toll-Like Receptors ; Arginase ; arginase II, human

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Contributing Institute(s):

1. United epigenomic platform (Schultze - PRECISE)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2017

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; Ebsco Academic Search ; IF >= 60 ; JCR ; SCOPUS ; Web of Science Core Collection ; Zoological Record

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