TY  - JOUR
AU  - McGovern, Naomi
AU  - Shin, Amanda
AU  - Low, Gillian
AU  - Low, Donovan
AU  - Duan, Kaibo
AU  - Yao, Leong Jing
AU  - Msallam, Rasha
AU  - Low, Ivy
AU  - Shadan, Nurhidaya Binte
AU  - Sumatoh, Hermi R
AU  - Soon, Erin
AU  - Lum, Josephine
AU  - Mok, Esther
AU  - Hubert, Sandra
AU  - See, Peter
AU  - Kunxiang, Edwin Huang
AU  - Lee, Yie Hou
AU  - Janela, Baptiste
AU  - Choolani, Mahesh
AU  - Mattar, Citra Nurfarah Zaini
AU  - Fan, Yiping
AU  - Lim, Tony Kiat Hon
AU  - Chan, Dedrick Kok Hong
AU  - Tan, Ker-Kan
AU  - Tam, John Kit Chung
AU  - Schuster, Christopher
AU  - Elbe-Bürger, Adelheid
AU  - Wang, Xiao-Nong
AU  - Bigley, Venetia
AU  - Collin, Matthew
AU  - Haniffa, Muzlifah
AU  - Schlitzer, Andreas
AU  - Poidinger, Michael
AU  - Albani, Salvatore
AU  - Larbi, Anis
AU  - Newell, Evan W
AU  - Chan, Jerry Kok Yen
AU  - Ginhoux, Florent
TI  - Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2.
JO  - Nature 
VL  - 546
IS  - 7660
SN  - 0028-0836
CY  - London [u.a.]
PB  - Nature Publ. Group65848
M1  - DZNE-2020-05661
SP  - 662-666
PY  - 2017
AB  - During gestation the developing human fetus is exposed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens from maternal cells, substances from ingested amniotic fluid, food antigens, and microbes. Yet the capacity of the fetal immune system, including antigen-presenting cells, to detect and respond to such stimuli remains unclear. In particular, dendritic cells, which are crucial for effective immunity and tolerance, remain poorly characterized in the developing fetus. Here we show that subsets of antigen-presenting cells can be identified in fetal tissues and are related to adult populations of antigen-presenting cells. Similar to adult dendritic cells, fetal dendritic cells migrate to lymph nodes and respond to toll-like receptor ligation; however, they differ markedly in their response to allogeneic antigens, strongly promoting regulatory T-cell induction and inhibiting T-cell tumour-necrosis factor-α production through arginase-2 activity. Our results reveal a previously unappreciated role of dendritic cells within the developing fetus and indicate that they mediate homeostatic immune-suppressive responses during gestation.
KW  - Adult
KW  - Arginase: metabolism
KW  - Cell Movement
KW  - Cell Proliferation
KW  - Cytokines: biosynthesis
KW  - Cytokines: immunology
KW  - Dendritic Cells: enzymology
KW  - Dendritic Cells: immunology
KW  - Fetus: cytology
KW  - Fetus: enzymology
KW  - Fetus: immunology
KW  - Humans
KW  - Immune Tolerance
KW  - Lymph Nodes: cytology
KW  - Lymph Nodes: immunology
KW  - T-Lymphocytes: cytology
KW  - T-Lymphocytes: immunology
KW  - T-Lymphocytes, Regulatory: cytology
KW  - T-Lymphocytes, Regulatory: immunology
KW  - Toll-Like Receptors: immunology
KW  - Cytokines (NLM Chemicals)
KW  - Toll-Like Receptors (NLM Chemicals)
KW  - Arginase (NLM Chemicals)
KW  - arginase II, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:28614294
C2  - pmc:PMC6588541
DO  - DOI:10.1038/nature22795
UR  - https://pub.dzne.de/record/139339
ER  -