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@ARTICLE{McGovern:139339,
      author       = {McGovern, Naomi and Shin, Amanda and Low, Gillian and Low,
                      Donovan and Duan, Kaibo and Yao, Leong Jing and Msallam,
                      Rasha and Low, Ivy and Shadan, Nurhidaya Binte and Sumatoh,
                      Hermi R and Soon, Erin and Lum, Josephine and Mok, Esther
                      and Hubert, Sandra and See, Peter and Kunxiang, Edwin Huang
                      and Lee, Yie Hou and Janela, Baptiste and Choolani, Mahesh
                      and Mattar, Citra Nurfarah Zaini and Fan, Yiping and Lim,
                      Tony Kiat Hon and Chan, Dedrick Kok Hong and Tan, Ker-Kan
                      and Tam, John Kit Chung and Schuster, Christopher and
                      Elbe-Bürger, Adelheid and Wang, Xiao-Nong and Bigley,
                      Venetia and Collin, Matthew and Haniffa, Muzlifah and
                      Schlitzer, Andreas and Poidinger, Michael and Albani,
                      Salvatore and Larbi, Anis and Newell, Evan W and Chan, Jerry
                      Kok Yen and Ginhoux, Florent},
      title        = {{H}uman fetal dendritic cells promote prenatal {T}-cell
                      immune suppression through arginase-2.},
      journal      = {Nature},
      volume       = {546},
      number       = {7660},
      issn         = {0028-0836},
      address      = {London [u.a.]},
      publisher    = {Nature Publ. Group65848},
      reportid     = {DZNE-2020-05661},
      pages        = {662-666},
      year         = {2017},
      abstract     = {During gestation the developing human fetus is exposed to a
                      diverse range of potentially immune-stimulatory molecules
                      including semi-allogeneic antigens from maternal cells,
                      substances from ingested amniotic fluid, food antigens, and
                      microbes. Yet the capacity of the fetal immune system,
                      including antigen-presenting cells, to detect and respond to
                      such stimuli remains unclear. In particular, dendritic
                      cells, which are crucial for effective immunity and
                      tolerance, remain poorly characterized in the developing
                      fetus. Here we show that subsets of antigen-presenting cells
                      can be identified in fetal tissues and are related to adult
                      populations of antigen-presenting cells. Similar to adult
                      dendritic cells, fetal dendritic cells migrate to lymph
                      nodes and respond to toll-like receptor ligation; however,
                      they differ markedly in their response to allogeneic
                      antigens, strongly promoting regulatory T-cell induction and
                      inhibiting T-cell tumour-necrosis factor-α production
                      through arginase-2 activity. Our results reveal a previously
                      unappreciated role of dendritic cells within the developing
                      fetus and indicate that they mediate homeostatic
                      immune-suppressive responses during gestation.},
      keywords     = {Adult / Arginase: metabolism / Cell Movement / Cell
                      Proliferation / Cytokines: biosynthesis / Cytokines:
                      immunology / Dendritic Cells: enzymology / Dendritic Cells:
                      immunology / Fetus: cytology / Fetus: enzymology / Fetus:
                      immunology / Humans / Immune Tolerance / Lymph Nodes:
                      cytology / Lymph Nodes: immunology / T-Lymphocytes: cytology
                      / T-Lymphocytes: immunology / T-Lymphocytes, Regulatory:
                      cytology / T-Lymphocytes, Regulatory: immunology / Toll-Like
                      Receptors: immunology / Cytokines (NLM Chemicals) /
                      Toll-Like Receptors (NLM Chemicals) / Arginase (NLM
                      Chemicals) / arginase II, human (NLM Chemicals)},
      cin          = {Schultze - PRECISE},
      ddc          = {500},
      cid          = {I:(DE-2719)1013031},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28614294},
      pmc          = {pmc:PMC6588541},
      doi          = {10.1038/nature22795},
      url          = {https://pub.dzne.de/record/139339},
}