guest ::
| Home > Publications Database > Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. > print |
| Home > Publications Database > Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. > print |
| 001 | 139339 | ||
| 005 | 20240321220612.0 | ||
| 024 | 7 | _ | |a 10.1038/nature22795 |2 doi |
| 024 | 7 | _ | |a pmid:28614294 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC6588541 |2 pmc |
| 024 | 7 | _ | |a 0028-0836 |2 ISSN |
| 024 | 7 | _ | |a 1476-4687 |2 ISSN |
| 024 | 7 | _ | |a altmetric:21064280 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-05661 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a McGovern, Naomi |b 0 |
| 245 | _ | _ | |a Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. |
| 260 | _ | _ | |a London [u.a.] |c 2017 |b Nature Publ. Group65848 |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2017-06-14 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2017-06-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1588081361_27570 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a During gestation the developing human fetus is exposed to a diverse range of potentially immune-stimulatory molecules including semi-allogeneic antigens from maternal cells, substances from ingested amniotic fluid, food antigens, and microbes. Yet the capacity of the fetal immune system, including antigen-presenting cells, to detect and respond to such stimuli remains unclear. In particular, dendritic cells, which are crucial for effective immunity and tolerance, remain poorly characterized in the developing fetus. Here we show that subsets of antigen-presenting cells can be identified in fetal tissues and are related to adult populations of antigen-presenting cells. Similar to adult dendritic cells, fetal dendritic cells migrate to lymph nodes and respond to toll-like receptor ligation; however, they differ markedly in their response to allogeneic antigens, strongly promoting regulatory T-cell induction and inhibiting T-cell tumour-necrosis factor-α production through arginase-2 activity. Our results reveal a previously unappreciated role of dendritic cells within the developing fetus and indicate that they mediate homeostatic immune-suppressive responses during gestation. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2017-06-01 |2 Crossref |u http://www.springer.com/tdm |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Cytokines |2 NLM Chemicals |
| 650 | _ | 7 | |a Toll-Like Receptors |2 NLM Chemicals |
| 650 | _ | 7 | |a Arginase |0 EC 3.5.3.1 |2 NLM Chemicals |
| 650 | _ | 7 | |a arginase II, human |0 EC 3.5.3.1 |2 NLM Chemicals |
| 650 | _ | 2 | |a Adult |2 MeSH |
| 650 | _ | 2 | |a Arginase: metabolism |2 MeSH |
| 650 | _ | 2 | |a Cell Movement |2 MeSH |
| 650 | _ | 2 | |a Cell Proliferation |2 MeSH |
| 650 | _ | 2 | |a Cytokines: biosynthesis |2 MeSH |
| 650 | _ | 2 | |a Cytokines: immunology |2 MeSH |
| 650 | _ | 2 | |a Dendritic Cells: enzymology |2 MeSH |
| 650 | _ | 2 | |a Dendritic Cells: immunology |2 MeSH |
| 650 | _ | 2 | |a Fetus: cytology |2 MeSH |
| 650 | _ | 2 | |a Fetus: enzymology |2 MeSH |
| 650 | _ | 2 | |a Fetus: immunology |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Immune Tolerance |2 MeSH |
| 650 | _ | 2 | |a Lymph Nodes: cytology |2 MeSH |
| 650 | _ | 2 | |a Lymph Nodes: immunology |2 MeSH |
| 650 | _ | 2 | |a T-Lymphocytes: cytology |2 MeSH |
| 650 | _ | 2 | |a T-Lymphocytes: immunology |2 MeSH |
| 650 | _ | 2 | |a T-Lymphocytes, Regulatory: cytology |2 MeSH |
| 650 | _ | 2 | |a T-Lymphocytes, Regulatory: immunology |2 MeSH |
| 650 | _ | 2 | |a Toll-Like Receptors: immunology |2 MeSH |
| 700 | 1 | _ | |a Shin, Amanda |b 1 |
| 700 | 1 | _ | |a Low, Gillian |b 2 |
| 700 | 1 | _ | |a Low, Donovan |b 3 |
| 700 | 1 | _ | |a Duan, Kaibo |b 4 |
| 700 | 1 | _ | |a Yao, Leong Jing |b 5 |
| 700 | 1 | _ | |a Msallam, Rasha |b 6 |
| 700 | 1 | _ | |a Low, Ivy |b 7 |
| 700 | 1 | _ | |a Shadan, Nurhidaya Binte |b 8 |
| 700 | 1 | _ | |a Sumatoh, Hermi R |b 9 |
| 700 | 1 | _ | |a Soon, Erin |b 10 |
| 700 | 1 | _ | |a Lum, Josephine |b 11 |
| 700 | 1 | _ | |a Mok, Esther |b 12 |
| 700 | 1 | _ | |a Hubert, Sandra |b 13 |
| 700 | 1 | _ | |a See, Peter |b 14 |
| 700 | 1 | _ | |a Kunxiang, Edwin Huang |b 15 |
| 700 | 1 | _ | |a Lee, Yie Hou |b 16 |
| 700 | 1 | _ | |a Janela, Baptiste |b 17 |
| 700 | 1 | _ | |a Choolani, Mahesh |b 18 |
| 700 | 1 | _ | |a Mattar, Citra Nurfarah Zaini |b 19 |
| 700 | 1 | _ | |a Fan, Yiping |b 20 |
| 700 | 1 | _ | |a Lim, Tony Kiat Hon |b 21 |
| 700 | 1 | _ | |a Chan, Dedrick Kok Hong |b 22 |
| 700 | 1 | _ | |a Tan, Ker-Kan |b 23 |
| 700 | 1 | _ | |a Tam, John Kit Chung |b 24 |
| 700 | 1 | _ | |a Schuster, Christopher |b 25 |
| 700 | 1 | _ | |a Elbe-Bürger, Adelheid |b 26 |
| 700 | 1 | _ | |a Wang, Xiao-Nong |b 27 |
| 700 | 1 | _ | |a Bigley, Venetia |b 28 |
| 700 | 1 | _ | |a Collin, Matthew |b 29 |
| 700 | 1 | _ | |a Haniffa, Muzlifah |b 30 |
| 700 | 1 | _ | |a Schlitzer, Andreas |0 P:(DE-2719)2813805 |b 31 |u dzne |
| 700 | 1 | _ | |a Poidinger, Michael |b 32 |
| 700 | 1 | _ | |a Albani, Salvatore |b 33 |
| 700 | 1 | _ | |a Larbi, Anis |b 34 |
| 700 | 1 | _ | |a Newell, Evan W |b 35 |
| 700 | 1 | _ | |a Chan, Jerry Kok Yen |b 36 |
| 700 | 1 | _ | |a Ginhoux, Florent |0 P:(DE-HGF)0 |b 37 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1038/nature22795 |b : Springer Science and Business Media LLC, 2017-06-01 |n 7660 |p 662-666 |3 journal-article |2 Crossref |t Nature |v 546 |y 2017 |x 0028-0836 |
| 773 | _ | _ | |a 10.1038/nature22795 |g Vol. 546, no. 7660, p. 662 - 666 |0 PERI:(DE-600)1413423-8 |n 7660 |q 546:7660<662 - 666 |p 662-666 |t Nature |v 546 |y 2017 |x 0028-0836 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588541 |
| 909 | C | O | |o oai:pub.dzne.de:139339 |p VDB |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 31 |6 P:(DE-2719)2813805 |
| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-342 |2 G:(DE-HGF)POF3-300 |v Disease Mechanisms and Model Systems |x 0 |
| 914 | 1 | _ | |y 2017 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b NATURE : 2021 |d 2022-11-29 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2022-11-29 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2022-11-29 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2022-11-29 |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2022-11-29 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2022-11-29 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2022-11-29 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2022-11-29 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |d 2022-11-29 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1040 |2 StatID |b Zoological Record |d 2022-11-29 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1060 |2 StatID |b Current Contents - Agriculture, Biology and Environmental Sciences |d 2022-11-29 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1150 |2 StatID |b Current Contents - Physical, Chemical and Earth Sciences |d 2022-11-29 |
| 915 | _ | _ | |a IF >= 60 |0 StatID:(DE-HGF)9960 |2 StatID |b NATURE : 2021 |d 2022-11-29 |
| 920 | 1 | _ | |0 I:(DE-2719)1013031 |k Schultze - PRECISE |l United epigenomic platform |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)5000031 |
| 980 | _ | _ | |a UNRESTRICTED |
| 999 | C | 5 | |a 10.1126/science.1164511 |9 -- missing cx lookup -- |2 Crossref |o 10.1126/science.1164511 |
| 999 | C | 5 | |a 10.1126/science.3051377 |9 -- missing cx lookup -- |2 Crossref |o 10.1126/science.3051377 |
| 999 | C | 5 | |a 10.1016/0378-3782(85)90174-4 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/0378-3782(85)90174-4 |
| 999 | C | 5 | |a 10.1038/sj.jp.7211290 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/sj.jp.7211290 |
| 999 | C | 5 | |a 10.1111/cea.12531 |9 -- missing cx lookup -- |2 Crossref |o 10.1111/cea.12531 |
| 999 | C | 5 | |a 10.1126/scitranslmed.3008599 |9 -- missing cx lookup -- |2 Crossref |o 10.1126/scitranslmed.3008599 |
| 999 | C | 5 | |a 10.1016/j.immuni.2012.04.012 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.immuni.2012.04.012 |
| 999 | C | 5 | |a 10.1016/j.immuni.2014.08.006 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.immuni.2014.08.006 |
| 999 | C | 5 | |a 10.1084/jem.20081747 |9 -- missing cx lookup -- |2 Crossref |o 10.1084/jem.20081747 |
| 999 | C | 5 | |a 10.1016/j.semcdb.2015.03.011 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.semcdb.2015.03.011 |
| 999 | C | 5 | |a 10.4049/jimmunol.1501928 |9 -- missing cx lookup -- |2 Crossref |o 10.4049/jimmunol.1501928 |
| 999 | C | 5 | |a 10.1016/j.immuni.2016.08.015 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.immuni.2016.08.015 |
| 999 | C | 5 | |a 10.1016/j.immuni.2004.06.014 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.immuni.2004.06.014 |
| 999 | C | 5 | |a 10.1038/nri2297 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/nri2297 |
| 999 | C | 5 | |a 10.1038/jid.2013.481 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/jid.2013.481 |
| 999 | C | 5 | |a 10.1084/jem.181.4.1445 |9 -- missing cx lookup -- |2 Crossref |o 10.1084/jem.181.4.1445 |
| 999 | C | 5 | |a 10.1016/j.ajpath.2015.05.006 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.ajpath.2015.05.006 |
| 999 | C | 5 | |a 10.1016/j.jcma.2013.07.006 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.jcma.2013.07.006 |
| 999 | C | 5 | |a 10.1056/NEJM199812033392302 |9 -- missing cx lookup -- |2 Crossref |o 10.1056/NEJM199812033392302 |
| 999 | C | 5 | |a 10.1084/jem.20060772 |9 -- missing cx lookup -- |2 Crossref |o 10.1084/jem.20060772 |
| 999 | C | 5 | |a 10.1084/jem.20060468 |9 -- missing cx lookup -- |2 Crossref |o 10.1084/jem.20060468 |
| 999 | C | 5 | |a 10.1038/nature12675 |9 -- missing cx lookup -- |2 Crossref |o 10.1038/nature12675 |
| 999 | C | 5 | |a 10.1126/scisignal.3135pe27 |9 -- missing cx lookup -- |2 Crossref |o 10.1126/scisignal.3135pe27 |
| 999 | C | 5 | |a 10.1016/j.cell.2016.09.031 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.cell.2016.09.031 |
| 999 | C | 5 | |a 10.1172/JCI68989 |9 -- missing cx lookup -- |2 Crossref |o 10.1172/JCI68989 |
| 999 | C | 5 | |2 Crossref |o |
| 999 | C | 5 | |a 10.1016/j.immuni.2013.04.011 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.immuni.2013.04.011 |
| 999 | C | 5 | |a 10.1016/S0166-4328(01)00297-2 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/S0166-4328(01)00297-2 |
| 999 | C | 5 | |a 10.1016/j.febslet.2004.07.055 |9 -- missing cx lookup -- |2 Crossref |o 10.1016/j.febslet.2004.07.055 |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|