%0 Journal Article
%A Marchetti, Giovanni
%A Tavosanis, Gaia
%T Steroid Hormone Ecdysone Signaling Specifies Mushroom Body Neuron Sequential Fate via Chinmo.
%J Current biology
%V 27
%N 19
%@ 0960-9822
%C London
%I Current Biology Ltd.
%M DZNE-2020-05870
%P 3017-3024.e4
%D 2017
%X The functional variety in neuronal composition of an adult brain is established during development. Recent studies proposed that interactions between genetic intrinsic programs and external cues are necessary to generate proper neural diversity [1]. However, the molecular mechanisms underlying this developmental process are still poorly understood. Three main subtypes of Drosophila mushroom body (MB) neurons are sequentially generated during development and provide a good example of developmental neural plasticity [2]. Our present data propose that the environmentally controlled steroid hormone ecdysone functions as a regulator of early-born MB neuron fate during larval-pupal transition. We found that the BTB-zinc finger factor Chinmo acts upstream of ecdysone signaling to promote a neuronal fate switch. Indeed, Chinmo regulates the expression of the ecdysone receptor B1 isoform to mediate the production of γ and α'β' MB neurons. In addition, we provide genetic evidence for a regulatory negative feedback loop driving the α'β' to αβ MB neuron transition in which ecdysone signaling in turn controls microRNA let-7 depression of Chinmo expression. Thus, our results uncover a novel interaction in the MB neural specification pathway for temporal control of neuronal identity by interplay between an extrinsic hormonal signal and an intrinsic transcription factor cascade.
%K Animals
%K Cell Differentiation
%K Drosophila Proteins: genetics
%K Drosophila Proteins: metabolism
%K Drosophila melanogaster: genetics
%K Drosophila melanogaster: growth & development
%K Drosophila melanogaster: metabolism
%K Ecdysone: metabolism
%K Gene Expression Regulation, Developmental
%K Larva: genetics
%K Larva: growth & development
%K Larva: metabolism
%K Mushroom Bodies: growth & development
%K Nerve Tissue Proteins: genetics
%K Nerve Tissue Proteins: metabolism
%K Neurons: physiology
%K Pupa: genetics
%K Pupa: growth & development
%K Pupa: metabolism
%K Receptors, Steroid: genetics
%K Receptors, Steroid: metabolism
%K Signal Transduction
%K Chinmo protein, Drosophila (NLM Chemicals)
%K Drosophila Proteins (NLM Chemicals)
%K Nerve Tissue Proteins (NLM Chemicals)
%K Receptors, Steroid (NLM Chemicals)
%K ecdysone receptor (NLM Chemicals)
%K Ecdysone (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28966087
%R 10.1016/j.cub.2017.08.037
%U https://pub.dzne.de/record/139548