Journal Article

DZNE-2020-05870

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Steroid Hormone Ecdysone Signaling Specifies Mushroom Body Neuron Sequential Fate via Chinmo.

Marchetti, G. (First author)DZNE* ; Tavosanis, G. (Last author)DZNE*

2017
Current Biology Ltd. London

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Please use a persistent id in citations: doi:10.1016/j.cub.2017.08.037

Abstract: The functional variety in neuronal composition of an adult brain is established during development. Recent studies proposed that interactions between genetic intrinsic programs and external cues are necessary to generate proper neural diversity [1]. However, the molecular mechanisms underlying this developmental process are still poorly understood. Three main subtypes of Drosophila mushroom body (MB) neurons are sequentially generated during development and provide a good example of developmental neural plasticity [2]. Our present data propose that the environmentally controlled steroid hormone ecdysone functions as a regulator of early-born MB neuron fate during larval-pupal transition. We found that the BTB-zinc finger factor Chinmo acts upstream of ecdysone signaling to promote a neuronal fate switch. Indeed, Chinmo regulates the expression of the ecdysone receptor B1 isoform to mediate the production of γ and α'β' MB neurons. In addition, we provide genetic evidence for a regulatory negative feedback loop driving the α'β' to αβ MB neuron transition in which ecdysone signaling in turn controls microRNA let-7 depression of Chinmo expression. Thus, our results uncover a novel interaction in the MB neural specification pathway for temporal control of neuronal identity by interplay between an extrinsic hormonal signal and an intrinsic transcription factor cascade.

Keyword(s): Animals (MeSH) ; Cell Differentiation (MeSH) ; Drosophila Proteins: genetics (MeSH) ; Drosophila Proteins: metabolism (MeSH) ; Drosophila melanogaster: genetics (MeSH) ; Drosophila melanogaster: growth & development (MeSH) ; Drosophila melanogaster: metabolism (MeSH) ; Ecdysone: metabolism (MeSH) ; Gene Expression Regulation, Developmental (MeSH) ; Larva: genetics (MeSH) ; Larva: growth & development (MeSH) ; Larva: metabolism (MeSH) ; Mushroom Bodies: growth & development (MeSH) ; Nerve Tissue Proteins: genetics (MeSH) ; Nerve Tissue Proteins: metabolism (MeSH) ; Neurons: physiology (MeSH) ; Pupa: genetics (MeSH) ; Pupa: growth & development (MeSH) ; Pupa: metabolism (MeSH) ; Receptors, Steroid: genetics (MeSH) ; Receptors, Steroid: metabolism (MeSH) ; Signal Transduction (MeSH) ; Chinmo protein, Drosophila ; Drosophila Proteins ; Nerve Tissue Proteins ; Receptors, Steroid ; ecdysone receptor ; Ecdysone

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Contributing Institute(s):

1. Dynamics of neuronal circuits (AG Tavosanis)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2017

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection ; Zoological Record

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