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@ARTICLE{Marchetti:139548,
      author       = {Marchetti, Giovanni and Tavosanis, Gaia},
      title        = {{S}teroid {H}ormone {E}cdysone {S}ignaling {S}pecifies
                      {M}ushroom {B}ody {N}euron {S}equential {F}ate via
                      {C}hinmo.},
      journal      = {Current biology},
      volume       = {27},
      number       = {19},
      issn         = {0960-9822},
      address      = {London},
      publisher    = {Current Biology Ltd.},
      reportid     = {DZNE-2020-05870},
      pages        = {3017-3024.e4},
      year         = {2017},
      abstract     = {The functional variety in neuronal composition of an adult
                      brain is established during development. Recent studies
                      proposed that interactions between genetic intrinsic
                      programs and external cues are necessary to generate proper
                      neural diversity [1]. However, the molecular mechanisms
                      underlying this developmental process are still poorly
                      understood. Three main subtypes of Drosophila mushroom body
                      (MB) neurons are sequentially generated during development
                      and provide a good example of developmental neural
                      plasticity [2]. Our present data propose that the
                      environmentally controlled steroid hormone ecdysone
                      functions as a regulator of early-born MB neuron fate during
                      larval-pupal transition. We found that the BTB-zinc finger
                      factor Chinmo acts upstream of ecdysone signaling to promote
                      a neuronal fate switch. Indeed, Chinmo regulates the
                      expression of the ecdysone receptor B1 isoform to mediate
                      the production of γ and α'β' MB neurons. In addition, we
                      provide genetic evidence for a regulatory negative feedback
                      loop driving the α'β' to αβ MB neuron transition in
                      which ecdysone signaling in turn controls microRNA let-7
                      depression of Chinmo expression. Thus, our results uncover a
                      novel interaction in the MB neural specification pathway for
                      temporal control of neuronal identity by interplay between
                      an extrinsic hormonal signal and an intrinsic transcription
                      factor cascade.},
      keywords     = {Animals / Cell Differentiation / Drosophila Proteins:
                      genetics / Drosophila Proteins: metabolism / Drosophila
                      melanogaster: genetics / Drosophila melanogaster: growth
                      $\&$ development / Drosophila melanogaster: metabolism /
                      Ecdysone: metabolism / Gene Expression Regulation,
                      Developmental / Larva: genetics / Larva: growth $\&$
                      development / Larva: metabolism / Mushroom Bodies: growth
                      $\&$ development / Nerve Tissue Proteins: genetics / Nerve
                      Tissue Proteins: metabolism / Neurons: physiology / Pupa:
                      genetics / Pupa: growth $\&$ development / Pupa: metabolism
                      / Receptors, Steroid: genetics / Receptors, Steroid:
                      metabolism / Signal Transduction / Chinmo protein,
                      Drosophila (NLM Chemicals) / Drosophila Proteins (NLM
                      Chemicals) / Nerve Tissue Proteins (NLM Chemicals) /
                      Receptors, Steroid (NLM Chemicals) / ecdysone receptor (NLM
                      Chemicals) / Ecdysone (NLM Chemicals)},
      cin          = {AG Tavosanis},
      ddc          = {570},
      cid          = {I:(DE-2719)1013018},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28966087},
      doi          = {10.1016/j.cub.2017.08.037},
      url          = {https://pub.dzne.de/record/139548},
}