Home > Publications Database > Steroid Hormone Ecdysone Signaling Specifies Mushroom Body Neuron Sequential Fate via Chinmo. > print

001     139548
005     20240321220635.0
024 7 _ |a 10.1016/j.cub.2017.08.037
|2 doi
024 7 _ |a pmid:28966087
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024 7 _ |a 0960-9822
|2 ISSN
024 7 _ |a 1879-0445
|2 ISSN
024 7 _ |a altmetric:26730866
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037 _ _ |a DZNE-2020-05870
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Marchetti, Giovanni
|0 P:(DE-2719)2810953
|b 0
|e First author
|u dzne
245 _ _ |a Steroid Hormone Ecdysone Signaling Specifies Mushroom Body Neuron Sequential Fate via Chinmo.
260 _ _ |a London
|c 2017
|b Current Biology Ltd.
264 _ 1 |3 print
|2 Crossref
|b Elsevier BV
|c 2017-10-01
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1591284411_13306
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336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a The functional variety in neuronal composition of an adult brain is established during development. Recent studies proposed that interactions between genetic intrinsic programs and external cues are necessary to generate proper neural diversity [1]. However, the molecular mechanisms underlying this developmental process are still poorly understood. Three main subtypes of Drosophila mushroom body (MB) neurons are sequentially generated during development and provide a good example of developmental neural plasticity [2]. Our present data propose that the environmentally controlled steroid hormone ecdysone functions as a regulator of early-born MB neuron fate during larval-pupal transition. We found that the BTB-zinc finger factor Chinmo acts upstream of ecdysone signaling to promote a neuronal fate switch. Indeed, Chinmo regulates the expression of the ecdysone receptor B1 isoform to mediate the production of γ and α'β' MB neurons. In addition, we provide genetic evidence for a regulatory negative feedback loop driving the α'β' to αβ MB neuron transition in which ecdysone signaling in turn controls microRNA let-7 depression of Chinmo expression. Thus, our results uncover a novel interaction in the MB neural specification pathway for temporal control of neuronal identity by interplay between an extrinsic hormonal signal and an intrinsic transcription factor cascade.
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
|0 G:(DE-HGF)POF3-342
|c POF3-342
|f POF III
|x 0
542 _ _ |i 2017-10-01
|2 Crossref
|u https://www.elsevier.com/tdm/userlicense/1.0/
542 _ _ |i 2018-10-09
|2 Crossref
|u http://www.elsevier.com/open-access/userlicense/1.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Chinmo protein, Drosophila
|2 NLM Chemicals
650 _ 7 |a Drosophila Proteins
|2 NLM Chemicals
650 _ 7 |a Nerve Tissue Proteins
|2 NLM Chemicals
650 _ 7 |a Receptors, Steroid
|2 NLM Chemicals
650 _ 7 |a ecdysone receptor
|2 NLM Chemicals
650 _ 7 |a Ecdysone
|0 3604-87-3
|2 NLM Chemicals
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Cell Differentiation
|2 MeSH
650 _ 2 |a Drosophila Proteins: genetics
|2 MeSH
650 _ 2 |a Drosophila Proteins: metabolism
|2 MeSH
650 _ 2 |a Drosophila melanogaster: genetics
|2 MeSH
650 _ 2 |a Drosophila melanogaster: growth & development
|2 MeSH
650 _ 2 |a Drosophila melanogaster: metabolism
|2 MeSH
650 _ 2 |a Ecdysone: metabolism
|2 MeSH
650 _ 2 |a Gene Expression Regulation, Developmental
|2 MeSH
650 _ 2 |a Larva: genetics
|2 MeSH
650 _ 2 |a Larva: growth & development
|2 MeSH
650 _ 2 |a Larva: metabolism
|2 MeSH
650 _ 2 |a Mushroom Bodies: growth & development
|2 MeSH
650 _ 2 |a Nerve Tissue Proteins: genetics
|2 MeSH
650 _ 2 |a Nerve Tissue Proteins: metabolism
|2 MeSH
650 _ 2 |a Neurons: physiology
|2 MeSH
650 _ 2 |a Pupa: genetics
|2 MeSH
650 _ 2 |a Pupa: growth & development
|2 MeSH
650 _ 2 |a Pupa: metabolism
|2 MeSH
650 _ 2 |a Receptors, Steroid: genetics
|2 MeSH
650 _ 2 |a Receptors, Steroid: metabolism
|2 MeSH
650 _ 2 |a Signal Transduction
|2 MeSH
700 1 _ |a Tavosanis, Gaia
|0 P:(DE-2719)2810271
|b 1
|e Last author
|u dzne
773 1 8 |a 10.1016/j.cub.2017.08.037
|b : Elsevier BV, 2017-10-01
|n 19
|p 3017-3024.e4
|3 journal-article
|2 Crossref
|t Current Biology
|v 27
|y 2017
|x 0960-9822
773 _ _ |a 10.1016/j.cub.2017.08.037
|g Vol. 27, no. 19, p. 3017 - 3024.e4
|0 PERI:(DE-600)2019214-9
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|p 3017-3024.e4
|t Current biology
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909 C O |o oai:pub.dzne.de:139548
|p VDB
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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|l Erkrankungen des Nervensystems
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