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@ARTICLE{Eichler:139697,
      author       = {Eichler, Tilly and Thyrian, Jochen Rene and Hertel,
                      Johannes and Richter, Steffen and Michalowsky, Bernhard and
                      Wucherer, Diana and Dreier, Adina and Kilimann, Ingo and
                      Teipel, Stefan and Hoffmann, Wolfgang},
      title        = {{P}atient {V}ariables {A}ssociated with the {A}ssignment of
                      a {F}ormal {D}ementia {D}iagnosis to {P}ositively {S}creened
                      {P}rimary {C}are {P}atients.},
      journal      = {Current Alzheimer research},
      volume       = {15},
      number       = {1},
      issn         = {1567-2050},
      address      = {Hilversum},
      publisher    = {Bentham Science Publ. Ltd.},
      reportid     = {DZNE-2020-06019},
      pages        = {44-50},
      year         = {2018},
      abstract     = {Main objective was to analyze the associations of patient
                      variables (depression, quality of life, anti-dementia drug
                      treatment, knowledge about dementia) with the assignment of
                      a formal diagnosis of dementia to community-dwelling primary
                      care patients who have screened positive for
                      dementia.DelpHi-MV (Dementia: life- and person-centered help
                      in Mecklenburg-Western Pomerania) is a general practitioner
                      based randomized controlled intervention trial. Present
                      analyses are based on cross-sectional data of 319 positively
                      screened patients (age 70+, living at home) who had not been
                      formally diagnosed with dementia before the screening. The
                      medical diagnoses (ICD-10) were retrieved from the patient's
                      medical records. Depression (Geriatric Depression Scale;
                      GDS), quality of life in Alzheimer's disease (Qol-AD),
                      knowledge about dementia, and anti-dementia drug treatment
                      were assessed after the screening test at the baseline
                      examination.At the baseline examination, 171 out of 319
                      patients $(54\%)$ had been formally diagnosed with dementia
                      after they have screened positive. Univariate comparisons
                      showed no statistically significant differences between
                      diagnosed and undiagnosed patients regarding depression
                      (GDS≥6: $11\%$ vs. $15\%;$ p=0.396), quality of life (mean
                      (SD): 2.8 (0.3) vs. 2.8 (0.4); p=0.833), and the knowledge
                      about dementia $(75\%$ vs. $75\%;$ p>0.999). Patients who
                      had received a formal diagnosis were more often treated with
                      anti-dementia drugs $(20\%$ vs. $11\%;$ p=0.040).
                      Multivariate analyses controlled for confounding variables
                      confirmed these findings.Present findings do not support
                      concerns that the assignment of a formal dementia diagnosis
                      after screening is associated with potential harms. If
                      confirmed in a prospective study, our data would suggest
                      that patients may benefit from being formally diagnosed
                      regarding anti-dementia drug treatment.},
      keywords     = {Aged / Aged, 80 and over / Cross-Sectional Studies /
                      Dementia: diagnosis / Dementia: drug therapy / Dementia:
                      epidemiology / Dementia: psychology / Depression:
                      epidemiology / Female / Health Knowledge, Attitudes,
                      Practice / Humans / Male / Nootropic Agents: therapeutic use
                      / Primary Health Care / Quality of Life / Nootropic Agents
                      (NLM Chemicals)},
      cin          = {AG Thyrian / AG Grabe / Magdeburg Pre 2020 / Translational
                      Health Care Research / Clinical Dementia Research Rostock
                      /Greifswald ; AG Teipel},
      ddc          = {610},
      cid          = {I:(DE-2719)1510800 / I:(DE-2719)5000001 /
                      I:(DE-2719)6000015 / I:(DE-2719)1510600 /
                      I:(DE-2719)1510100},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28891445},
      doi          = {10.2174/1567205014666170908095707},
      url          = {https://pub.dzne.de/record/139697},
}