Journal Article (Review Article)

DZNE-2020-06039

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png GABAergic Transmission during Brain Development: Multiple Effects at Multiple Stages.

Kirmse, K. (Corresponding author) ; Hübner, C. A. ; Isbrandt, D.DZNE* ; Witte, O. W. ; Holthoff, K.

2018
Sage London [u.a.]

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Please use a persistent id in citations: doi:10.1177/1073858417701382

Abstract: In recent years, considerable progress has been achieved in deciphering the cellular and network functions of GABAergic transmission in the intact developing brain. First, in vivo studies in non-mammalian and mammalian species confirmed the long-held assumption that GABA acts as a mainly depolarizing neurotransmitter at early developmental stages. At the same time, GABAergic transmission was shown to spatiotemporally constrain spontaneous cortical activity, whereas firm evidence for GABAergic excitation in vivo is currently missing. Second, there is a growing body of evidence indicating that depolarizing GABA may contribute to the activity-dependent refinement of neural circuits. Third, alterations in GABA actions have been causally linked to developmental brain disorders and identified as potential targets of timed prophylactic interventions. In this article, we review these major recent findings and argue that both depolarizing and inhibitory GABA actions may be crucial for physiological brain maturation.

Keyword(s): Animals (MeSH) ; Brain: growth & development (MeSH) ; Brain: metabolism (MeSH) ; Humans (MeSH) ; Synaptic Transmission: physiology (MeSH) ; gamma-Aminobutyric Acid: metabolism (MeSH) ; gamma-Aminobutyric Acid

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Contributing Institute(s):

1. Experimental Neurophysiology (AG Isbrandt)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; National-Konsortium ; SCOPUS ; Web of Science Core Collection

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