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@ARTICLE{Chen:139736,
      author       = {Chen, Xufeng and Aslam, Muhammad and Gollisch, Tim and
                      Allen, Kevin and Engelhardt, Jakob},
      title        = {{CKAMP}44 modulates integration of visual inputs in the
                      lateral geniculate nucleus.},
      journal      = {Nature Communications},
      volume       = {9},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2020-06058},
      pages        = {261},
      year         = {2018},
      abstract     = {Relay neurons in the dorsal lateral geniculate nucleus
                      (dLGN) receive excitatory inputs from retinal ganglion cells
                      (RGCs). Retinogeniculate synapses are characterized by a
                      prominent short-term depression of AMPA receptor
                      (AMPAR)-mediated currents, but the underlying mechanisms and
                      its function for visual integration are not known. Here we
                      identify CKAMP44 as a crucial auxiliary subunit of AMPARs in
                      dLGN relay neurons, where it increases AMPAR-mediated
                      current amplitudes and modulates gating of AMPARs.
                      Importantly, CKAMP44 is responsible for the distinctive
                      short-term depression in retinogeniculate synapses by
                      reducing the rate of recovery from desensitization of
                      AMPARs. Genetic deletion of CKAMP44 strongly reduces
                      synaptic short-term depression, which leads to increased
                      spike probability of relay neurons when activated with
                      high-frequency inputs from retinogeniculate synapses.
                      Finally, in vivo recordings reveal augmented ON- and
                      OFF-responses of dLGN neurons in CKAMP44 knockout
                      (CKAMP44-/-) mice, demonstrating the importance of CKAMP44
                      for modulating synaptic short-term depression and visual
                      input integration.},
      keywords     = {Animals / Electroretinography / Excitatory Postsynaptic
                      Potentials: physiology / Female / Geniculate Bodies:
                      cytology / Geniculate Bodies: metabolism / Geniculate
                      Bodies: physiology / Mice, Inbred C57BL / Mice, Knockout /
                      Nerve Tissue Proteins: genetics / Nerve Tissue Proteins:
                      metabolism / Neurons: metabolism / Neurons: physiology /
                      Photic Stimulation / Receptors, AMPA: metabolism / Retina:
                      cytology / Retina: metabolism / Retina: physiology /
                      Synapses: physiology / Synaptic Transmission: genetics /
                      Synaptic Transmission: physiology / CKAMP44 protein, mouse
                      (NLM Chemicals) / Nerve Tissue Proteins (NLM Chemicals) /
                      Receptors, AMPA (NLM Chemicals)},
      cin          = {AG Engelhardt},
      ddc          = {500},
      cid          = {I:(DE-2719)1013023},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29343769},
      pmc          = {pmc:PMC5772470},
      doi          = {10.1038/s41467-017-02415-1},
      url          = {https://pub.dzne.de/record/139736},
}