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| 001 | 139736 | ||
| 005 | 20240511120151.0 | ||
| 024 | 7 | _ | |a 10.1038/s41467-017-02415-1 |2 doi |
| 024 | 7 | _ | |a pmid:29343769 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5772470 |2 pmc |
| 024 | 7 | _ | |a altmetric:31869872 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-06058 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Chen, Xufeng |0 P:(DE-2719)2810594 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a CKAMP44 modulates integration of visual inputs in the lateral geniculate nucleus. |
| 260 | _ | _ | |a [London] |c 2018 |b Nature Publishing Group UK |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2018-01-17 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2018-12-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1715346389_4830 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Relay neurons in the dorsal lateral geniculate nucleus (dLGN) receive excitatory inputs from retinal ganglion cells (RGCs). Retinogeniculate synapses are characterized by a prominent short-term depression of AMPA receptor (AMPAR)-mediated currents, but the underlying mechanisms and its function for visual integration are not known. Here we identify CKAMP44 as a crucial auxiliary subunit of AMPARs in dLGN relay neurons, where it increases AMPAR-mediated current amplitudes and modulates gating of AMPARs. Importantly, CKAMP44 is responsible for the distinctive short-term depression in retinogeniculate synapses by reducing the rate of recovery from desensitization of AMPARs. Genetic deletion of CKAMP44 strongly reduces synaptic short-term depression, which leads to increased spike probability of relay neurons when activated with high-frequency inputs from retinogeniculate synapses. Finally, in vivo recordings reveal augmented ON- and OFF-responses of dLGN neurons in CKAMP44 knockout (CKAMP44-/-) mice, demonstrating the importance of CKAMP44 for modulating synaptic short-term depression and visual input integration. |
| 536 | _ | _ | |a 341 - Molecular Signaling (POF3-341) |0 G:(DE-HGF)POF3-341 |c POF3-341 |f POF III |x 0 |
| 542 | _ | _ | |i 2018-01-17 |2 Crossref |u http://creativecommons.org/licenses/by/4.0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a CKAMP44 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Nerve Tissue Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Receptors, AMPA |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Electroretinography |2 MeSH |
| 650 | _ | 2 | |a Excitatory Postsynaptic Potentials: physiology |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Geniculate Bodies: cytology |2 MeSH |
| 650 | _ | 2 | |a Geniculate Bodies: metabolism |2 MeSH |
| 650 | _ | 2 | |a Geniculate Bodies: physiology |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Mice, Knockout |2 MeSH |
| 650 | _ | 2 | |a Nerve Tissue Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Nerve Tissue Proteins: metabolism |2 MeSH |
| 650 | _ | 2 | |a Neurons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Neurons: physiology |2 MeSH |
| 650 | _ | 2 | |a Photic Stimulation |2 MeSH |
| 650 | _ | 2 | |a Receptors, AMPA: metabolism |2 MeSH |
| 650 | _ | 2 | |a Retina: cytology |2 MeSH |
| 650 | _ | 2 | |a Retina: metabolism |2 MeSH |
| 650 | _ | 2 | |a Retina: physiology |2 MeSH |
| 650 | _ | 2 | |a Synapses: physiology |2 MeSH |
| 650 | _ | 2 | |a Synaptic Transmission: genetics |2 MeSH |
| 650 | _ | 2 | |a Synaptic Transmission: physiology |2 MeSH |
| 700 | 1 | _ | |a Aslam, Muhammad |0 P:(DE-2719)2810579 |b 1 |u dzne |
| 700 | 1 | _ | |a Gollisch, Tim |b 2 |
| 700 | 1 | _ | |a Allen, Kevin |b 3 |
| 700 | 1 | _ | |a Engelhardt, Jakob |0 P:(DE-2719)2810460 |b 4 |e Last author |u dzne |
| 773 | 1 | 8 | |a 10.1038/s41467-017-02415-1 |b : Springer Science and Business Media LLC, 2018-01-17 |n 1 |p 261 |3 journal-article |2 Crossref |t Nature Communications |v 9 |y 2018 |x 2041-1723 |
| 773 | _ | _ | |a 10.1038/s41467-017-02415-1 |g Vol. 9, no. 1, p. 261 |0 PERI:(DE-600)2553671-0 |n 1 |q 9:1<261 |p 261 |t Nature Communications |v 9 |y 2018 |x 2041-1723 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/139736/files/DZNE-2020-06058.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/139736/files/DZNE-2020-06058.pdf?subformat=pdfa |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772470 |
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| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2810594 |
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| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 4 |6 P:(DE-2719)2810460 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Erkrankungen des Nervensystems |1 G:(DE-HGF)POF3-340 |0 G:(DE-HGF)POF3-341 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-300 |4 G:(DE-HGF)POF |v Molecular Signaling |x 0 |
| 914 | 1 | _ | |y 2018 |
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| 920 | 1 | _ | |0 I:(DE-2719)1013023 |k AG Engelhardt |l Synaptic Signalling and Neurodegeneration |x 0 |
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