Journal Article (Review Article)

DZNE-2020-06140

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Circuit Motif as a Conceptual Tool for Multilevel Neuroscience.

Braganza, O. (Corresponding author) ; Beck, H. (Last author)DZNE*

2018
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.tins.2018.01.002

Abstract: Modern neuroscientific techniques that specifically manipulate and measure neuronal activity in behaving animals now allow bridging of the gap from the cellular to the behavioral level. However, in doing so, they also pose new challenges. Research using incompletely defined manipulations in a high-dimensional space without clear hypotheses is likely to suffer from multiple well-known conceptual and statistical problems. In this context it is essential to develop hypotheses with testable implications across levels. Here we propose that a focus on circuit motifs can help achieve this goal. Viewing neural structures as an assembly of circuit motif building blocks is not new. However, recent tool advances have made it possible to extensively map, specifically manipulate, and quantitatively investigate circuit motifs and thereby reexamine their relevance to brain function.

Keyword(s): Animals (MeSH) ; Behavior: physiology (MeSH) ; Brain: physiology (MeSH) ; Humans (MeSH) ; Nerve Net: physiology (MeSH) ; Neurons: physiology (MeSH) ; Neurosciences: methods (MeSH) ; Optogenetics: methods (MeSH)

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Contributing Institute(s):

1. U Preclinical Researchers - Bonn (U Preclinical Researchers - Bonn)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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