%0 Journal Article
%A van Uem, Janet M T
%A Cerff, Bernhard
%A Kampmeyer, Malte
%A Prinzen, Jos
%A Zuidema, Menno
%A Hobert, Markus A
%A Gräber, Susanne
%A Berg, Daniela
%A Maetzler, Walter
%A Liepelt-Scarfone, Inga
%T The association between objectively measured physical activity, depression, cognition, and health-related quality of life in Parkinson's disease.
%J Parkinsonism & related disorders
%V 48
%@ 1353-8020
%C Amsterdam [u.a.]
%I Elsevier Science
%M DZNE-2020-06187
%P 74-81
%D 2018
%X Lower levels of physical activity are associated with lower Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD). We evaluated the influence of quantitative physical activity parameters among other (disease-related) features representing other domains of the WHO International model for classification of Function, Disability, and Health (ICF) on HRQoL in PD.Home-based movement data (DynaPort MiniMod®) was collected in 47 PD patients. Nine stepwise regression models were calculated, with consecutive outcome variables: Parkinson's Disease Questionnaire (PDQ) Summary Index (SI), PDQ-Mobility, PDQ-Activities of Daily Living (ADL). Demographic variables, disease-specific features, and quantitative physical activity parameters, were included as predicting variables in all analyses. The following three physical activity parameters were alternately included for both sedentary and active episodes: 'percentage' of 24 h spent within these episodes, 'number of bouts', and 'mean bout lengths' (MBL).Depression and 'Total Energy Expenditure' were the main predictors of overall HRQoL (PDQ-SI), independent of the permutation of activity parameters. The same parameters predicted the PDQ-Mobility score. However, this result was altered when 'MBL' parameters were included into the model, 'MBL' of sedentary episodes additionally predicted HRQoL-Mobility. The PDQ-ADL score was associated with demographic, motor, and non-motor variables including cognitive status. After exclusion of demented PD patients, older age and cognitive impairment no longer constrained HRQoL-ADL.For the first time, we showed the influence of objective, home-based measured physical activity among depression and cognition on HRQoL in PD. This suggests that a multifactorial treatment approach would be most successful to increase HRQoL in PD.
%K Accelerometry
%K Adult
%K Aged
%K Aged, 80 and over
%K Cognition Disorders: etiology
%K Cross-Sectional Studies
%K Depression: etiology
%K Exercise
%K Female
%K Humans
%K Male
%K Middle Aged
%K Neuropsychological Tests
%K Parkinson Disease: complications
%K Parkinson Disease: psychology
%K Psychiatric Status Rating Scales
%K Quality of Life: psychology
%K Severity of Illness Index
%K Surveys and Questionnaires
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29307560
%R 10.1016/j.parkreldis.2017.12.023
%U https://pub.dzne.de/record/139865