Journal Article

DZNE-2020-06187

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The association between objectively measured physical activity, depression, cognition, and health-related quality of life in Parkinson's disease.

van Uem, J. M. T. (First author)DZNE* ; Cerff, B.DZNE* ; Kampmeyer, M.DZNE* ; Prinzen, J. ; Zuidema, M. ; Hobert, M. A.DZNE* ; Gräber, S.DZNE* ; Berg, D.DZNE* ; Maetzler, W.DZNE* ; Liepelt-Scarfone, I. (Last author)DZNE*

2018
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.parkreldis.2017.12.023

Abstract: Lower levels of physical activity are associated with lower Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD). We evaluated the influence of quantitative physical activity parameters among other (disease-related) features representing other domains of the WHO International model for classification of Function, Disability, and Health (ICF) on HRQoL in PD.Home-based movement data (DynaPort MiniMod®) was collected in 47 PD patients. Nine stepwise regression models were calculated, with consecutive outcome variables: Parkinson's Disease Questionnaire (PDQ) Summary Index (SI), PDQ-Mobility, PDQ-Activities of Daily Living (ADL). Demographic variables, disease-specific features, and quantitative physical activity parameters, were included as predicting variables in all analyses. The following three physical activity parameters were alternately included for both sedentary and active episodes: 'percentage' of 24 h spent within these episodes, 'number of bouts', and 'mean bout lengths' (MBL).Depression and 'Total Energy Expenditure' were the main predictors of overall HRQoL (PDQ-SI), independent of the permutation of activity parameters. The same parameters predicted the PDQ-Mobility score. However, this result was altered when 'MBL' parameters were included into the model, 'MBL' of sedentary episodes additionally predicted HRQoL-Mobility. The PDQ-ADL score was associated with demographic, motor, and non-motor variables including cognitive status. After exclusion of demented PD patients, older age and cognitive impairment no longer constrained HRQoL-ADL.For the first time, we showed the influence of objective, home-based measured physical activity among depression and cognition on HRQoL in PD. This suggests that a multifactorial treatment approach would be most successful to increase HRQoL in PD.

Keyword(s): Accelerometry (MeSH) ; Adult (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Cognition Disorders: etiology (MeSH) ; Cross-Sectional Studies (MeSH) ; Depression: etiology (MeSH) ; Exercise (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Neuropsychological Tests (MeSH) ; Parkinson Disease: complications (MeSH) ; Parkinson Disease: psychology (MeSH) ; Psychiatric Status Rating Scales (MeSH) ; Quality of Life: psychology (MeSH) ; Severity of Illness Index (MeSH) ; Surveys and Questionnaires (MeSH)

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Contributing Institute(s):

1. DZNE before 2020 (Pre 2020)
2. Functional Neurogeriatrics (AG Maetzler)
3. Parkinson's Disease Genetics (AG Berg ; AG Berg)
4. Ext Universitätsklinikum Tübingen (Ext UKT)
5. Core ICRU (Core ICRU)
6. Parkinson Genetics (AG Gasser)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)
2. 345 - Population Studies and Genetics (POF3-345) (POF3-345)

Appears in the scientific report 2018

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; IF < 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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