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000139865 0247_ $$2doi$$a10.1016/j.parkreldis.2017.12.023
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000139865 0247_ $$2ISSN$$a1353-8020
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000139865 037__ $$aDZNE-2020-06187
000139865 041__ $$aEnglish
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000139865 1001_ $$0P:(DE-2719)9000322$$avan Uem, Janet M T$$b0$$eFirst author$$udzne
000139865 245__ $$aThe association between objectively measured physical activity, depression, cognition, and health-related quality of life in Parkinson's disease.
000139865 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2018
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000139865 520__ $$aLower levels of physical activity are associated with lower Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD). We evaluated the influence of quantitative physical activity parameters among other (disease-related) features representing other domains of the WHO International model for classification of Function, Disability, and Health (ICF) on HRQoL in PD.Home-based movement data (DynaPort MiniMod®) was collected in 47 PD patients. Nine stepwise regression models were calculated, with consecutive outcome variables: Parkinson's Disease Questionnaire (PDQ) Summary Index (SI), PDQ-Mobility, PDQ-Activities of Daily Living (ADL). Demographic variables, disease-specific features, and quantitative physical activity parameters, were included as predicting variables in all analyses. The following three physical activity parameters were alternately included for both sedentary and active episodes: 'percentage' of 24 h spent within these episodes, 'number of bouts', and 'mean bout lengths' (MBL).Depression and 'Total Energy Expenditure' were the main predictors of overall HRQoL (PDQ-SI), independent of the permutation of activity parameters. The same parameters predicted the PDQ-Mobility score. However, this result was altered when 'MBL' parameters were included into the model, 'MBL' of sedentary episodes additionally predicted HRQoL-Mobility. The PDQ-ADL score was associated with demographic, motor, and non-motor variables including cognitive status. After exclusion of demented PD patients, older age and cognitive impairment no longer constrained HRQoL-ADL.For the first time, we showed the influence of objective, home-based measured physical activity among depression and cognition on HRQoL in PD. This suggests that a multifactorial treatment approach would be most successful to increase HRQoL in PD.
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000139865 650_2 $$2MeSH$$aAccelerometry
000139865 650_2 $$2MeSH$$aAdult
000139865 650_2 $$2MeSH$$aAged
000139865 650_2 $$2MeSH$$aAged, 80 and over
000139865 650_2 $$2MeSH$$aCognition Disorders: etiology
000139865 650_2 $$2MeSH$$aCross-Sectional Studies
000139865 650_2 $$2MeSH$$aDepression: etiology
000139865 650_2 $$2MeSH$$aExercise
000139865 650_2 $$2MeSH$$aFemale
000139865 650_2 $$2MeSH$$aHumans
000139865 650_2 $$2MeSH$$aMale
000139865 650_2 $$2MeSH$$aMiddle Aged
000139865 650_2 $$2MeSH$$aNeuropsychological Tests
000139865 650_2 $$2MeSH$$aParkinson Disease: complications
000139865 650_2 $$2MeSH$$aParkinson Disease: psychology
000139865 650_2 $$2MeSH$$aPsychiatric Status Rating Scales
000139865 650_2 $$2MeSH$$aQuality of Life: psychology
000139865 650_2 $$2MeSH$$aSeverity of Illness Index
000139865 650_2 $$2MeSH$$aSurveys and Questionnaires
000139865 7001_ $$0P:(DE-2719)9000046$$aCerff, Bernhard$$b1$$udzne
000139865 7001_ $$0P:(DE-2719)9000147$$aKampmeyer, Malte$$b2$$udzne
000139865 7001_ $$0P:(DE-HGF)0$$aPrinzen, Jos$$b3
000139865 7001_ $$0P:(DE-HGF)0$$aZuidema, Menno$$b4
000139865 7001_ $$0P:(DE-2719)9000133$$aHobert, Markus A$$b5$$udzne
000139865 7001_ $$0P:(DE-2719)2810662$$aGräber, Susanne$$b6$$udzne
000139865 7001_ $$0P:(DE-2719)2000059$$aBerg, Daniela$$b7$$udzne
000139865 7001_ $$0P:(DE-2719)2810915$$aMaetzler, Walter$$b8$$udzne
000139865 7001_ $$0P:(DE-2719)2109499$$aLiepelt-Scarfone, Inga$$b9$$eLast author$$udzne
000139865 77318 $$2Crossref$$3journal-article$$a10.1016/j.parkreldis.2017.12.023$$b : Elsevier BV, 2018-03-01$$p74-81$$tParkinsonism & Related Disorders$$v48$$x1353-8020$$y2018
000139865 773__ $$0PERI:(DE-600)2027635-7$$a10.1016/j.parkreldis.2017.12.023$$gVol. 48, p. 74 - 81$$p74-81$$q48<74 - 81$$tParkinsonism & related disorders$$v48$$x1353-8020$$y2018
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