TY  - JOUR
AU  - van Uem, Janet M T
AU  - Cerff, Bernhard
AU  - Kampmeyer, Malte
AU  - Prinzen, Jos
AU  - Zuidema, Menno
AU  - Hobert, Markus A
AU  - Gräber, Susanne
AU  - Berg, Daniela
AU  - Maetzler, Walter
AU  - Liepelt-Scarfone, Inga
TI  - The association between objectively measured physical activity, depression, cognition, and health-related quality of life in Parkinson's disease.
JO  - Parkinsonism & related disorders
VL  - 48
SN  - 1353-8020
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2020-06187
SP  - 74-81
PY  - 2018
AB  - Lower levels of physical activity are associated with lower Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD). We evaluated the influence of quantitative physical activity parameters among other (disease-related) features representing other domains of the WHO International model for classification of Function, Disability, and Health (ICF) on HRQoL in PD.Home-based movement data (DynaPort MiniMod®) was collected in 47 PD patients. Nine stepwise regression models were calculated, with consecutive outcome variables: Parkinson's Disease Questionnaire (PDQ) Summary Index (SI), PDQ-Mobility, PDQ-Activities of Daily Living (ADL). Demographic variables, disease-specific features, and quantitative physical activity parameters, were included as predicting variables in all analyses. The following three physical activity parameters were alternately included for both sedentary and active episodes: 'percentage' of 24 h spent within these episodes, 'number of bouts', and 'mean bout lengths' (MBL).Depression and 'Total Energy Expenditure' were the main predictors of overall HRQoL (PDQ-SI), independent of the permutation of activity parameters. The same parameters predicted the PDQ-Mobility score. However, this result was altered when 'MBL' parameters were included into the model, 'MBL' of sedentary episodes additionally predicted HRQoL-Mobility. The PDQ-ADL score was associated with demographic, motor, and non-motor variables including cognitive status. After exclusion of demented PD patients, older age and cognitive impairment no longer constrained HRQoL-ADL.For the first time, we showed the influence of objective, home-based measured physical activity among depression and cognition on HRQoL in PD. This suggests that a multifactorial treatment approach would be most successful to increase HRQoL in PD.
KW  - Accelerometry
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Cognition Disorders: etiology
KW  - Cross-Sectional Studies
KW  - Depression: etiology
KW  - Exercise
KW  - Female
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Neuropsychological Tests
KW  - Parkinson Disease: complications
KW  - Parkinson Disease: psychology
KW  - Psychiatric Status Rating Scales
KW  - Quality of Life: psychology
KW  - Severity of Illness Index
KW  - Surveys and Questionnaires
LB  - PUB:(DE-HGF)16
C6  - pmid:29307560
DO  - DOI:10.1016/j.parkreldis.2017.12.023
UR  - https://pub.dzne.de/record/139865
ER  -