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@ARTICLE{vanUem:139865,
      author       = {van Uem, Janet M T and Cerff, Bernhard and Kampmeyer, Malte
                      and Prinzen, Jos and Zuidema, Menno and Hobert, Markus A and
                      Gräber, Susanne and Berg, Daniela and Maetzler, Walter and
                      Liepelt-Scarfone, Inga},
      title        = {{T}he association between objectively measured physical
                      activity, depression, cognition, and health-related quality
                      of life in {P}arkinson's disease.},
      journal      = {Parkinsonism $\&$ related disorders},
      volume       = {48},
      issn         = {1353-8020},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-06187},
      pages        = {74-81},
      year         = {2018},
      abstract     = {Lower levels of physical activity are associated with lower
                      Health-Related Quality of Life (HRQoL) in Parkinson's
                      disease (PD). We evaluated the influence of quantitative
                      physical activity parameters among other (disease-related)
                      features representing other domains of the WHO International
                      model for classification of Function, Disability, and Health
                      (ICF) on HRQoL in PD.Home-based movement data (DynaPort
                      MiniMod®) was collected in 47 PD patients. Nine stepwise
                      regression models were calculated, with consecutive outcome
                      variables: Parkinson's Disease Questionnaire (PDQ) Summary
                      Index (SI), PDQ-Mobility, PDQ-Activities of Daily Living
                      (ADL). Demographic variables, disease-specific features, and
                      quantitative physical activity parameters, were included as
                      predicting variables in all analyses. The following three
                      physical activity parameters were alternately included for
                      both sedentary and active episodes: 'percentage' of 24 h
                      spent within these episodes, 'number of bouts', and 'mean
                      bout lengths' (MBL).Depression and 'Total Energy
                      Expenditure' were the main predictors of overall HRQoL
                      (PDQ-SI), independent of the permutation of activity
                      parameters. The same parameters predicted the PDQ-Mobility
                      score. However, this result was altered when 'MBL'
                      parameters were included into the model, 'MBL' of sedentary
                      episodes additionally predicted HRQoL-Mobility. The PDQ-ADL
                      score was associated with demographic, motor, and non-motor
                      variables including cognitive status. After exclusion of
                      demented PD patients, older age and cognitive impairment no
                      longer constrained HRQoL-ADL.For the first time, we showed
                      the influence of objective, home-based measured physical
                      activity among depression and cognition on HRQoL in PD. This
                      suggests that a multifactorial treatment approach would be
                      most successful to increase HRQoL in PD.},
      keywords     = {Accelerometry / Adult / Aged / Aged, 80 and over /
                      Cognition Disorders: etiology / Cross-Sectional Studies /
                      Depression: etiology / Exercise / Female / Humans / Male /
                      Middle Aged / Neuropsychological Tests / Parkinson Disease:
                      complications / Parkinson Disease: psychology / Psychiatric
                      Status Rating Scales / Quality of Life: psychology /
                      Severity of Illness Index / Surveys and Questionnaires},
      cin          = {Pre 2020 / AG Maetzler / AG Berg ; AG Berg / Ext UKT / Core
                      ICRU / AG Gasser},
      ddc          = {610},
      cid          = {I:(DE-2719)999999 / I:(DE-2719)5000024 / I:(DE-2719)5000055
                      / I:(DE-2719)5000058 / I:(DE-2719)1240005 /
                      I:(DE-2719)1210000},
      pnm          = {344 - Clinical and Health Care Research (POF3-344) / 345 -
                      Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-344 / G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29307560},
      doi          = {10.1016/j.parkreldis.2017.12.023},
      url          = {https://pub.dzne.de/record/139865},
}