Home > Publications Database > The association between objectively measured physical activity, depression, cognition, and health-related quality of life in Parkinson's disease. > print

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024 7 _ |a 10.1016/j.parkreldis.2017.12.023
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037 _ _ |a DZNE-2020-06187
041 _ _ |a English
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100 1 _ |a van Uem, Janet M T
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245 _ _ |a The association between objectively measured physical activity, depression, cognition, and health-related quality of life in Parkinson's disease.
260 _ _ |a Amsterdam [u.a.]
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264 _ 1 |3 print
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|b Elsevier BV
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520 _ _ |a Lower levels of physical activity are associated with lower Health-Related Quality of Life (HRQoL) in Parkinson's disease (PD). We evaluated the influence of quantitative physical activity parameters among other (disease-related) features representing other domains of the WHO International model for classification of Function, Disability, and Health (ICF) on HRQoL in PD.Home-based movement data (DynaPort MiniMod®) was collected in 47 PD patients. Nine stepwise regression models were calculated, with consecutive outcome variables: Parkinson's Disease Questionnaire (PDQ) Summary Index (SI), PDQ-Mobility, PDQ-Activities of Daily Living (ADL). Demographic variables, disease-specific features, and quantitative physical activity parameters, were included as predicting variables in all analyses. The following three physical activity parameters were alternately included for both sedentary and active episodes: 'percentage' of 24 h spent within these episodes, 'number of bouts', and 'mean bout lengths' (MBL).Depression and 'Total Energy Expenditure' were the main predictors of overall HRQoL (PDQ-SI), independent of the permutation of activity parameters. The same parameters predicted the PDQ-Mobility score. However, this result was altered when 'MBL' parameters were included into the model, 'MBL' of sedentary episodes additionally predicted HRQoL-Mobility. The PDQ-ADL score was associated with demographic, motor, and non-motor variables including cognitive status. After exclusion of demented PD patients, older age and cognitive impairment no longer constrained HRQoL-ADL.For the first time, we showed the influence of objective, home-based measured physical activity among depression and cognition on HRQoL in PD. This suggests that a multifactorial treatment approach would be most successful to increase HRQoL in PD.
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650 _ 2 |a Accelerometry
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Cognition Disorders: etiology
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650 _ 2 |a Cross-Sectional Studies
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650 _ 2 |a Depression: etiology
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650 _ 2 |a Exercise
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650 _ 2 |a Female
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650 _ 2 |a Humans
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650 _ 2 |a Male
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650 _ 2 |a Middle Aged
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650 _ 2 |a Neuropsychological Tests
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650 _ 2 |a Parkinson Disease: complications
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650 _ 2 |a Parkinson Disease: psychology
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650 _ 2 |a Psychiatric Status Rating Scales
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650 _ 2 |a Quality of Life: psychology
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700 1 _ |a Cerff, Bernhard
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700 1 _ |a Kampmeyer, Malte
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700 1 _ |a Prinzen, Jos
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700 1 _ |a Zuidema, Menno
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700 1 _ |a Hobert, Markus A
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700 1 _ |a Gräber, Susanne
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700 1 _ |a Berg, Daniela
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700 1 _ |a Maetzler, Walter
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700 1 _ |a Liepelt-Scarfone, Inga
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773 1 8 |a 10.1016/j.parkreldis.2017.12.023
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|t Parkinsonism & Related Disorders
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773 _ _ |a 10.1016/j.parkreldis.2017.12.023
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