Journal Article (Review Article)

DZNE-2020-06246

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.

Lewczuk, P. (Corresponding author) ; Riederer, P. ; O'Bryant, S. E. ; Verbeek, M. M. ; Dubois, B. ; Visser, P. J. ; Jellinger, K. A. ; Engelborghs, S. ; Ramirez, A. ; Parnetti, L. ; Jack, C. R. ; Teunissen, C. E. ; Hampel, H. ; Lleó, A. ; Jessen, F.DZNE* ; Glodzik, L. ; de Leon, M. J. ; Fagan, A. M. ; Molinuevo, J. L. ; Jansen, W. J. ; Winblad, B. ; Shaw, L. M. ; Andreasson, U. ; Otto, M. ; Mollenhauer, B. ; Wiltfang, J.DZNE* ; Turner, M. R. ; Zerr, I.DZNE* ; Handels, R. ; Thompson, A. G. ; Johansson, G. ; Ermann, N. ; Trojanowski, J. Q. ; Karaca, I. ; Wagner, H. ; Oeckl, P. ; van Waalwijk van Doorn, L. ; Bjerke, M. ; Kapogiannis, D. ; Kuiperij, H. B. ; Farotti, L. ; Li, Y. ; Gordon, B. A. ; Epelbaum, S. ; Vos, S. J. B. ; Klijn, C. J. M. ; Van Nostrand, W. E. ; Minguillon, C. ; Schmitz, M.DZNE* ; Gallo, C. ; Lopez Mato, A. ; Thibaut, F. ; Lista, S. ; Alcolea, D. ; Zetterberg, H. ; Blennow, K. ; Kornhuber, J. ; Members of the WFSBP Task Force Working on this Topic: Peter Riederer, C. G.

2018
Taylor & Francis Group Abingdon

This record in other databases:    

Please use a persistent id in citations: doi:10.1080/15622975.2017.1375556

Abstract: In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. New concepts of Alzheimer's disease (AD) and the conceptual interactions between AD and dementia due to AD were developed, resulting in two sets for diagnostic/research criteria. Procedures for pre-analytical sample handling, biobanking, analyses and post-analytical interpretation of the results were intensively studied and optimised. A global quality control project was introduced to evaluate and monitor the inter-centre variability in measurements with the goal of harmonisation of results. Contexts of use and how to approach candidate biomarkers in biological specimens other than cerebrospinal fluid (CSF), e.g. blood, were precisely defined. Important development was achieved in neuroimaging techniques, including studies comparing amyloid-β positron emission tomography results to fluid-based modalities. Similarly, development in research laboratory technologies, such as ultra-sensitive methods, raises our hopes to further improve analytical and diagnostic accuracy of classic and novel candidate biomarkers. Synergistically, advancement in clinical trials of anti-dementia therapies energises and motivates the efforts to find and optimise the most reliable early diagnostic modalities. Finally, the first studies were published addressing the potential of cost-effectiveness of the biomarkers-based diagnosis of neurodegenerative disorders.

Keyword(s): Biological Psychiatry: standards (MeSH) ; Biomarkers: blood (MeSH) ; Biomarkers: cerebrospinal fluid (MeSH) ; Consensus (MeSH) ; Dementia: blood (MeSH) ; Dementia: cerebrospinal fluid (MeSH) ; Dementia: diagnosis (MeSH) ; Humans (MeSH) ; Neurodegenerative Diseases: blood (MeSH) ; Neurodegenerative Diseases: cerebrospinal fluid (MeSH) ; Neurodegenerative Diseases: diagnosis (MeSH) ; Societies, Medical: standards (MeSH) ; Biomarkers

---

Contributing Institute(s):

1. Patient studies cologne (AG Jessen)
2. Alzheimer Biomarker and Clinical Study Group (AG Wiltfang)
3. Translational Studies and Biomarkers (AG Zerr)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)
2. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2018

---

Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

---