Journal Article (Review Article)

DZNE-2020-06286

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Elucidating Neuronal Mechanisms Using Intracellular Recordings during Behavior.

Lee, A. K. (Corresponding author) ; Brecht, M. (Last author)DZNE*

2018
Elsevier Science Amsterdam [u.a.]

This record in other databases:    

Please use a persistent id in citations: doi:10.1016/j.tins.2018.03.014

Abstract: Intracellular recording allows measurement and perturbation of the membrane potential of identified neurons with sub-millisecond and sub-millivolt precision. This gives intracellular recordings a unique capacity to provide rich information about individual cells (e.g., high-resolution characterization of inputs, outputs, excitability, and structure). Hence, such recordings can elucidate the mechanisms that underlie fundamental phenomena, such as brain state, sparse coding, gating, gain modulation, and learning. Technical developments have increased the range of behaviors during which intracellular recording methods can be employed, such as in freely moving animals and head-fixed animals actively performing tasks, including in virtual environments. Such advances, and the combination of intracellular recordings with genetic and imaging techniques, have enabled investigation of the mechanisms that underlie neural computations during natural and trained behaviors.

Keyword(s): Action Potentials: physiology (MeSH) ; Animals (MeSH) ; Behavior, Animal: physiology (MeSH) ; Brain: cytology (MeSH) ; Neurons: physiology (MeSH) ; Wakefulness (MeSH)

---

Contributing Institute(s):

1. Microcircuits of Memory (AG Brecht)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2018

---

Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

---