%0 Journal Article
%A Dedic, Nina
%A Kühne, Claudia
%A Jakovcevski, Mira
%A Hartmann, Jakob
%A Genewsky, Andreas J
%A Gomes, Karina S
%A Anderzhanova, Elmira
%A Pöhlmann, Max L
%A Chang, Simon
%A Kolarz, Adam
%A Vogl, Annette M
%A Dine, Julien
%A Metzger, Michael W
%A Schmid, Bianca
%A Almada, Rafael C
%A Ressler, Kerry J
%A Wotjak, Carsten T
%A Grinevich, Valery
%A Chen, Alon
%A Schmidt, Mathias V
%A Wurst, Wolfgang
%A Refojo, Damian
%A Deussing, Jan M
%T Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.
%J Nature reviews / Neuroscience
%V 21
%N 6
%@ 1097-6256
%C London
%I Nature Publ. Group58142
%M DZNE-2020-06290
%P 803-807
%D 2018
%X The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
%K Amygdala: cytology
%K Amygdala: physiology
%K Animals
%K Anxiety: psychology
%K Calcium-Calmodulin-Dependent Protein Kinase Type 2: physiology
%K Corticotropin-Releasing Hormone: deficiency
%K Corticotropin-Releasing Hormone: pharmacology
%K Dendritic Spines: ultrastructure
%K Dopamine: metabolism
%K GABAergic Neurons: physiology
%K Injections
%K Male
%K Mice
%K Mice, Knockout
%K Motor Activity
%K Optogenetics
%K Pain Perception
%K Receptors, Corticotropin-Releasing Hormone: metabolism
%K Ventral Tegmental Area: cytology
%K Ventral Tegmental Area: physiology
%K CRF receptor type 2 (NLM Chemicals)
%K Receptors, Corticotropin-Releasing Hormone (NLM Chemicals)
%K CRF receptor type 1 (NLM Chemicals)
%K Corticotropin-Releasing Hormone (NLM Chemicals)
%K Calcium-Calmodulin-Dependent Protein Kinase Type 2 (NLM Chemicals)
%K Camk2a protein, mouse (NLM Chemicals)
%K Dopamine (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29786085
%2 pmc:PMC6951443
%R 10.1038/s41593-018-0151-z
%U https://pub.dzne.de/record/139968