Journal Article

DZNE-2020-06290

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.

Dedic, N. ; Kühne, C. ; Jakovcevski, M. ; Hartmann, J. ; Genewsky, A. J. ; Gomes, K. S. ; Anderzhanova, E. ; Pöhlmann, M. L. ; Chang, S. ; Kolarz, A. ; Vogl, A. M. ; Dine, J. ; Metzger, M. W. ; Schmid, B. ; Almada, R. C. ; Ressler, K. J. ; Wotjak, C. T. ; Grinevich, V. ; Chen, A. ; Schmidt, M. V. ; Wurst, W.DZNE* ; Refojo, D. ; Deussing, J. M. (Corresponding author)

2018
Nature Publ. Group58142 London

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Please use a persistent id in citations: doi:10.1038/s41593-018-0151-z

Abstract: The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.

Keyword(s): Amygdala: cytology (MeSH) ; Amygdala: physiology (MeSH) ; Animals (MeSH) ; Anxiety: psychology (MeSH) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2: physiology (MeSH) ; Corticotropin-Releasing Hormone: deficiency (MeSH) ; Corticotropin-Releasing Hormone: pharmacology (MeSH) ; Dendritic Spines: ultrastructure (MeSH) ; Dopamine: metabolism (MeSH) ; GABAergic Neurons: physiology (MeSH) ; Injections (MeSH) ; Male (MeSH) ; Mice (MeSH) ; Mice, Knockout (MeSH) ; Motor Activity (MeSH) ; Optogenetics (MeSH) ; Pain Perception (MeSH) ; Receptors, Corticotropin-Releasing Hormone: metabolism (MeSH) ; Ventral Tegmental Area: cytology (MeSH) ; Ventral Tegmental Area: physiology (MeSH) ; CRF receptor type 2 ; Receptors, Corticotropin-Releasing Hormone ; CRF receptor type 1 ; Corticotropin-Releasing Hormone ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 ; Camk2a protein, mouse ; Dopamine

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Contributing Institute(s):

1. Genome Engineering (AG Wurst)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 30 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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