TY  - JOUR
AU  - Dedic, Nina
AU  - Kühne, Claudia
AU  - Jakovcevski, Mira
AU  - Hartmann, Jakob
AU  - Genewsky, Andreas J
AU  - Gomes, Karina S
AU  - Anderzhanova, Elmira
AU  - Pöhlmann, Max L
AU  - Chang, Simon
AU  - Kolarz, Adam
AU  - Vogl, Annette M
AU  - Dine, Julien
AU  - Metzger, Michael W
AU  - Schmid, Bianca
AU  - Almada, Rafael C
AU  - Ressler, Kerry J
AU  - Wotjak, Carsten T
AU  - Grinevich, Valery
AU  - Chen, Alon
AU  - Schmidt, Mathias V
AU  - Wurst, Wolfgang
AU  - Refojo, Damian
AU  - Deussing, Jan M
TI  - Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety.
JO  - Nature reviews / Neuroscience
VL  - 21
IS  - 6
SN  - 1097-6256
CY  - London
PB  - Nature Publ. Group58142
M1  - DZNE-2020-06290
SP  - 803-807
PY  - 2018
AB  - The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH-dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
KW  - Amygdala: cytology
KW  - Amygdala: physiology
KW  - Animals
KW  - Anxiety: psychology
KW  - Calcium-Calmodulin-Dependent Protein Kinase Type 2: physiology
KW  - Corticotropin-Releasing Hormone: deficiency
KW  - Corticotropin-Releasing Hormone: pharmacology
KW  - Dendritic Spines: ultrastructure
KW  - Dopamine: metabolism
KW  - GABAergic Neurons: physiology
KW  - Injections
KW  - Male
KW  - Mice
KW  - Mice, Knockout
KW  - Motor Activity
KW  - Optogenetics
KW  - Pain Perception
KW  - Receptors, Corticotropin-Releasing Hormone: metabolism
KW  - Ventral Tegmental Area: cytology
KW  - Ventral Tegmental Area: physiology
KW  - CRF receptor type 2 (NLM Chemicals)
KW  - Receptors, Corticotropin-Releasing Hormone (NLM Chemicals)
KW  - CRF receptor type 1 (NLM Chemicals)
KW  - Corticotropin-Releasing Hormone (NLM Chemicals)
KW  - Calcium-Calmodulin-Dependent Protein Kinase Type 2 (NLM Chemicals)
KW  - Camk2a protein, mouse (NLM Chemicals)
KW  - Dopamine (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:29786085
C2  - pmc:PMC6951443
DO  - DOI:10.1038/s41593-018-0151-z
UR  - https://pub.dzne.de/record/139968
ER  -