%0 Journal Article
%A Peitz, Michael
%A Bechler, Tamara
%A Thiele, Cornelia
%A Veltel, Monika
%A Bloschies, Melanie
%A Fliessbach, Klaus
%A Ramirez, Alfredo
%A Brüstle, Oliver
%T Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype.
%J Stem cell research
%V 29
%@ 1873-5061
%C Amsterdam [u.a.]
%I Elsevier
%M DZNE-2020-06325
%P 250-253
%D 2018
%X Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE ε4/ε4 allele.
%K Kruppel-Like Factor 4
%K Aged, 80 and over
%K Alzheimer Disease: diagnosis
%K Alzheimer Disease: genetics
%K Alzheimer Disease: metabolism
%K Alzheimer Disease: pathology
%K Apolipoprotein E4: genetics
%K Apolipoprotein E4: metabolism
%K Blood Cells: metabolism
%K Blood Cells: pathology
%K Cellular Reprogramming Techniques
%K Genotype
%K Humans
%K Induced Pluripotent Stem Cells: metabolism
%K Induced Pluripotent Stem Cells: pathology
%K Male
%K Polymorphism, Single Nucleotide
%K Transcription Factors: biosynthesis
%K Transcription Factors: genetics
%K Apolipoprotein E4 (NLM Chemicals)
%K Transcription Factors (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29753274
%R 10.1016/j.scr.2018.04.011
%U https://pub.dzne.de/record/140003