guest ::
| Home > Publications Database > Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype. |
| Home > Publications Database > Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype. |
| Journal Article | DZNE-2020-06325 |
; ; ; ; ; ; ;
2018
Elsevier
Amsterdam [u.a.]
This record in other databases: 
Please use a persistent id in citations: doi:10.1016/j.scr.2018.04.011
Abstract: Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE ε4/ε4 allele.
Keyword(s): Kruppel-Like Factor 4 (MeSH) ; Aged, 80 and over (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Alzheimer Disease: genetics (MeSH) ; Alzheimer Disease: metabolism (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Apolipoprotein E4: genetics (MeSH) ; Apolipoprotein E4: metabolism (MeSH) ; Blood Cells: metabolism (MeSH) ; Blood Cells: pathology (MeSH) ; Cellular Reprogramming Techniques (MeSH) ; Genotype (MeSH) ; Humans (MeSH) ; Induced Pluripotent Stem Cells: metabolism (MeSH) ; Induced Pluripotent Stem Cells: pathology (MeSH) ; Male (MeSH) ; Polymorphism, Single Nucleotide (MeSH) ; Transcription Factors: biosynthesis (MeSH) ; Transcription Factors: genetics (MeSH) ; Apolipoprotein E4 ; Transcription Factors
; 
; 
; 
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; DOAJ Seal ; IF < 5 ; JCR ; SCOPUS ; Web of Science Core Collection
|
The record appears in these collections: |
PDF
PDF (PDFA)