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000140003 037__ $$aDZNE-2020-06325
000140003 041__ $$aEnglish
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000140003 1001_ $$0P:(DE-2719)9000249$$aPeitz, Michael$$b0$$eFirst author$$udzne
000140003 245__ $$aBlood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype.
000140003 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2018
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000140003 520__ $$aAlzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE ε4/ε4 allele.
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000140003 542__ $$2Crossref$$i2018-05-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
000140003 542__ $$2Crossref$$i2018-04-22$$uhttp://creativecommons.org/licenses/by-nc-nd/4.0/
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000140003 650_7 $$2NLM Chemicals$$aApolipoprotein E4
000140003 650_7 $$2NLM Chemicals$$aTranscription Factors
000140003 650_2 $$2MeSH$$aKruppel-Like Factor 4
000140003 650_2 $$2MeSH$$aAged, 80 and over
000140003 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000140003 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000140003 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000140003 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000140003 650_2 $$2MeSH$$aApolipoprotein E4: genetics
000140003 650_2 $$2MeSH$$aApolipoprotein E4: metabolism
000140003 650_2 $$2MeSH$$aBlood Cells: metabolism
000140003 650_2 $$2MeSH$$aBlood Cells: pathology
000140003 650_2 $$2MeSH$$aCellular Reprogramming Techniques
000140003 650_2 $$2MeSH$$aGenotype
000140003 650_2 $$2MeSH$$aHumans
000140003 650_2 $$2MeSH$$aInduced Pluripotent Stem Cells: metabolism
000140003 650_2 $$2MeSH$$aInduced Pluripotent Stem Cells: pathology
000140003 650_2 $$2MeSH$$aMale
000140003 650_2 $$2MeSH$$aPolymorphism, Single Nucleotide
000140003 650_2 $$2MeSH$$aTranscription Factors: biosynthesis
000140003 650_2 $$2MeSH$$aTranscription Factors: genetics
000140003 7001_ $$0P:(DE-HGF)0$$aBechler, Tamara$$b1
000140003 7001_ $$0P:(DE-2719)2811348$$aThiele, Cornelia$$b2$$udzne
000140003 7001_ $$0P:(DE-HGF)0$$aVeltel, Monika$$b3
000140003 7001_ $$0P:(DE-HGF)0$$aBloschies, Melanie$$b4
000140003 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b5$$udzne
000140003 7001_ $$0P:(DE-HGF)0$$aRamirez, Alfredo$$b6
000140003 7001_ $$0P:(DE-HGF)0$$aBrüstle, Oliver$$b7$$eCorresponding author
000140003 77318 $$2Crossref$$3journal-article$$a10.1016/j.scr.2018.04.011$$b : Elsevier BV, 2018-05-01$$p250-253$$tStem Cell Research$$v29$$x1873-5061$$y2018
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