TY  - JOUR
AU  - Peitz, Michael
AU  - Bechler, Tamara
AU  - Thiele, Cornelia
AU  - Veltel, Monika
AU  - Bloschies, Melanie
AU  - Fliessbach, Klaus
AU  - Ramirez, Alfredo
AU  - Brüstle, Oliver
TI  - Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype.
JO  - Stem cell research
VL  - 29
SN  - 1873-5061
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DZNE-2020-06325
SP  - 250-253
PY  - 2018
AB  - Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE ε4/ε4 allele.
KW  - Kruppel-Like Factor 4
KW  - Aged, 80 and over
KW  - Alzheimer Disease: diagnosis
KW  - Alzheimer Disease: genetics
KW  - Alzheimer Disease: metabolism
KW  - Alzheimer Disease: pathology
KW  - Apolipoprotein E4: genetics
KW  - Apolipoprotein E4: metabolism
KW  - Blood Cells: metabolism
KW  - Blood Cells: pathology
KW  - Cellular Reprogramming Techniques
KW  - Genotype
KW  - Humans
KW  - Induced Pluripotent Stem Cells: metabolism
KW  - Induced Pluripotent Stem Cells: pathology
KW  - Male
KW  - Polymorphism, Single Nucleotide
KW  - Transcription Factors: biosynthesis
KW  - Transcription Factors: genetics
KW  - Apolipoprotein E4 (NLM Chemicals)
KW  - Transcription Factors (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:29753274
DO  - DOI:10.1016/j.scr.2018.04.011
UR  - https://pub.dzne.de/record/140003
ER  -