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@ARTICLE{Peitz:140003,
      author       = {Peitz, Michael and Bechler, Tamara and Thiele, Cornelia and
                      Veltel, Monika and Bloschies, Melanie and Fliessbach, Klaus
                      and Ramirez, Alfredo and Brüstle, Oliver},
      title        = {{B}lood-derived integration-free i{PS} cell line
                      {UKB}i011-{A} from a diagnosed male {A}lzheimer's disease
                      patient with {APOE} ɛ4/ɛ4 genotype.},
      journal      = {Stem cell research},
      volume       = {29},
      issn         = {1873-5061},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-06325},
      pages        = {250-253},
      year         = {2018},
      abstract     = {Alzheimer's disease (AD) is most the frequent
                      neurodegenerative disease, and the APOE ε4 allele is the
                      most prominent risk factor for late-onset AD. Here, we
                      present an iPSC line generated from peripheral blood cells
                      of a male AD patient employing Sendai virus vectors encoding
                      the transcription factors OCT4, SOX2, KLF4 and c-MYC. The
                      characterized iPSC line expresses typical human pluripotency
                      markers and shows differentiation into all three germ
                      layers, complete reprogramming vector clearance, a normal
                      SNP genotype and maintenance of the APOE ε4/ε4 allele.},
      keywords     = {Kruppel-Like Factor 4 / Aged, 80 and over / Alzheimer
                      Disease: diagnosis / Alzheimer Disease: genetics / Alzheimer
                      Disease: metabolism / Alzheimer Disease: pathology /
                      Apolipoprotein E4: genetics / Apolipoprotein E4: metabolism
                      / Blood Cells: metabolism / Blood Cells: pathology /
                      Cellular Reprogramming Techniques / Genotype / Humans /
                      Induced Pluripotent Stem Cells: metabolism / Induced
                      Pluripotent Stem Cells: pathology / Male / Polymorphism,
                      Single Nucleotide / Transcription Factors: biosynthesis /
                      Transcription Factors: genetics / Apolipoprotein E4 (NLM
                      Chemicals) / Transcription Factors (NLM Chemicals)},
      cin          = {Cell Programming Unit / Patient Studies Bonn},
      ddc          = {570},
      cid          = {I:(DE-2719)1013013 / I:(DE-2719)1011101},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29753274},
      doi          = {10.1016/j.scr.2018.04.011},
      url          = {https://pub.dzne.de/record/140003},
}