Home > Publications Database > Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype. > print

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024 7 _ |a 10.1016/j.scr.2018.04.011
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024 7 _ |a pmid:29753274
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024 7 _ |a 1873-5061
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024 7 _ |a 1876-7753
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037 _ _ |a DZNE-2020-06325
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Peitz, Michael
|0 P:(DE-2719)9000249
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|e First author
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245 _ _ |a Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype.
260 _ _ |a Amsterdam [u.a.]
|c 2018
|b Elsevier
264 _ 1 |3 print
|2 Crossref
|b Elsevier BV
|c 2018-05-01
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE ε4/ε4 allele.
536 _ _ |a 344 - Clinical and Health Care Research (POF3-344)
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542 _ _ |i 2018-05-01
|2 Crossref
|u https://www.elsevier.com/tdm/userlicense/1.0/
542 _ _ |i 2018-04-22
|2 Crossref
|u http://creativecommons.org/licenses/by-nc-nd/4.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Apolipoprotein E4
|2 NLM Chemicals
650 _ 7 |a Transcription Factors
|2 NLM Chemicals
650 _ 2 |a Kruppel-Like Factor 4
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Alzheimer Disease: diagnosis
|2 MeSH
650 _ 2 |a Alzheimer Disease: genetics
|2 MeSH
650 _ 2 |a Alzheimer Disease: metabolism
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Apolipoprotein E4: genetics
|2 MeSH
650 _ 2 |a Apolipoprotein E4: metabolism
|2 MeSH
650 _ 2 |a Blood Cells: metabolism
|2 MeSH
650 _ 2 |a Blood Cells: pathology
|2 MeSH
650 _ 2 |a Cellular Reprogramming Techniques
|2 MeSH
650 _ 2 |a Genotype
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Induced Pluripotent Stem Cells: metabolism
|2 MeSH
650 _ 2 |a Induced Pluripotent Stem Cells: pathology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Polymorphism, Single Nucleotide
|2 MeSH
650 _ 2 |a Transcription Factors: biosynthesis
|2 MeSH
650 _ 2 |a Transcription Factors: genetics
|2 MeSH
700 1 _ |a Bechler, Tamara
|0 P:(DE-HGF)0
|b 1
700 1 _ |a Thiele, Cornelia
|0 P:(DE-2719)2811348
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700 1 _ |a Veltel, Monika
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700 1 _ |a Bloschies, Melanie
|0 P:(DE-HGF)0
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700 1 _ |a Fliessbach, Klaus
|0 P:(DE-2719)2811326
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700 1 _ |a Ramirez, Alfredo
|0 P:(DE-HGF)0
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700 1 _ |a Brüstle, Oliver
|0 P:(DE-HGF)0
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|e Corresponding author
773 1 8 |a 10.1016/j.scr.2018.04.011
|b : Elsevier BV, 2018-05-01
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|t Stem Cell Research
|v 29
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773 _ _ |a 10.1016/j.scr.2018.04.011
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856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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