%0 Journal Article
%A Höglinger, G. U.
%A Respondek, G.
%A Kovacs, G. G.
%T New classification of tauopathies.
%J Revue neurologique
%V 174
%N 9
%@ 0035-3787
%C Issy-les-Moulineaux
%I Elsevier Masson
%M DZNE-2020-06606
%P 664-668
%D 2018
%X Tauopathies are a group of neurodegenerative diseases characterized by pathological intracellular deposits of the protein tau. Isoform composition, morphology and anatomical distribution of cellular tau-immunoreactivities are defining distinct tauopathies as molecular pathological disease entities. The clinical spectrum of tauopathies includes syndromes with primary motor symptoms and with primary cognitive dysfunction. The traditional syndrome-based classification is currently being complemented by a molecular-pathological classification. While the syndrome-based classification is helpful to select symptomatic therapies, and to generate clinical working hypotheses about underlying etiologies, the molecular-pathological classification is most important for the development and application of molecularly tailored disease-modifying therapies.
%K Humans
%K Neurodegenerative Diseases: classification
%K Neurodegenerative Diseases: genetics
%K Supranuclear Palsy, Progressive: classification
%K Supranuclear Palsy, Progressive: genetics
%K Supranuclear Palsy, Progressive: physiopathology
%K Tauopathies: classification
%K Tauopathies: genetics
%K Tauopathies: physiopathology
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30098799
%R 10.1016/j.neurol.2018.07.001
%U https://pub.dzne.de/record/140284