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| Journal Article (Review Article) | DZNE-2020-06606 |
; ;
2018
Elsevier Masson
Issy-les-Moulineaux
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Please use a persistent id in citations: doi:10.1016/j.neurol.2018.07.001
Abstract: Tauopathies are a group of neurodegenerative diseases characterized by pathological intracellular deposits of the protein tau. Isoform composition, morphology and anatomical distribution of cellular tau-immunoreactivities are defining distinct tauopathies as molecular pathological disease entities. The clinical spectrum of tauopathies includes syndromes with primary motor symptoms and with primary cognitive dysfunction. The traditional syndrome-based classification is currently being complemented by a molecular-pathological classification. While the syndrome-based classification is helpful to select symptomatic therapies, and to generate clinical working hypotheses about underlying etiologies, the molecular-pathological classification is most important for the development and application of molecularly tailored disease-modifying therapies.
Keyword(s): Humans (MeSH) ; Neurodegenerative Diseases: classification (MeSH) ; Neurodegenerative Diseases: genetics (MeSH) ; Supranuclear Palsy, Progressive: classification (MeSH) ; Supranuclear Palsy, Progressive: genetics (MeSH) ; Supranuclear Palsy, Progressive: physiopathology (MeSH) ; Tauopathies: classification (MeSH) ; Tauopathies: genetics (MeSH) ; Tauopathies: physiopathology (MeSH)
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